RyR Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine functions as a potent modulator of ryanodine receptors (RyRs) by selectively binding to their high-affinity sites, inducing a conformational shift that alters calcium ion permeability. This interaction stabilizes the open state of the channel, enhancing calcium release from the sarcoplasmic reticulum. The unique cyclic structure of Ryanodine contributes to its specificity and affinity, influencing the dynamics of calcium signaling and cellular excitability in muscle tissues. | ||||||
Flecainide | 54143-55-4 | sc-219833 | 100 mg | $372.00 | ||
Flecainide acts as a selective blocker of sodium channels, exhibiting a unique mechanism that stabilizes the inactivated state of these channels. This interaction disrupts the normal ion flow, leading to a reduction in excitability and conduction velocity in cardiac tissues. Its distinct molecular structure allows for specific binding to the channel's voltage-sensing domains, influencing the kinetics of channel recovery and altering action potential duration. This modulation plays a critical role in cardiac electrophysiology. | ||||||
Flecainide-d3 | 127413-31-4 | sc-211511 | 1 mg | $377.00 | ||
Flecainide-d3 is a deuterated derivative that enhances the stability of its molecular interactions, particularly with ion channels. Its unique isotopic composition influences reaction kinetics, leading to altered binding affinities and enhanced selectivity. The presence of deuterium may also affect the vibrational modes of the molecule, potentially impacting its solubility and diffusion properties. This distinct behavior allows for nuanced exploration of ion channel dynamics and their regulatory mechanisms. | ||||||
4-Chloro-3-ethylphenol | 14143-32-9 | sc-254644 | 25 g | $35.00 | ||
4-Chloro-3-ethylphenol exhibits intriguing molecular interactions, particularly through its halogen substituent, which can enhance hydrogen bonding and dipole-dipole interactions. This compound's unique electronic structure influences its reactivity, allowing it to participate in electrophilic aromatic substitution reactions. Additionally, its hydrophobic ethyl group contributes to its solubility characteristics, affecting its distribution in various environments and potentially altering its interaction with biological membranes. | ||||||