RSP3 Activators
RSP3 Activators are a set of compounds that primarily function through the modulation of the cAMP signaling pathway. Compounds such as Forskolin, 8-Br-cAMP, and Isoproterenol function by increasing the intracellular levels of cAMP, either through direct activation of adenylate cyclase or by acting as an agonist at the beta-adrenergic receptor. Elevated cAMP levels lead to the activation of protein kinase A (PKA), which phosphorylates RSP3, leading to its functional activation. H-89 dihydrochloride, on the other hand, works by inhibiting PKA, increasing the pool of unphosphorylated PKA that can then phosphorylate and activate RSP3.
Other compounds within this class, such as Rolipram, IBMX, Vinpocetine, Zaprinast, Cilostazol, Pentoxyfylline, Theophylline, and Papaverine, function by inhibiting various types of phosphodiesterases, which are enzymes responsible for the breakdown of cAMP. By inhibiting these enzymes, these compounds effectively increase the intracellular levels of cAMP. As with the previous group of compounds, this increase in cAMP leads to the activation of PKA, which then phosphorylates and activates RSP3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is known to activate the adenylate cyclase enzyme, which in turn increases intracellular levels of cyclic adenosine monophosphate (cAMP). Increased cAMP levels can activate protein kinase A (PKA), which phosphorylates RSP3, leading to its functional activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog. This compound can directly activate PKA, which then phosphorylates RSP3, enhancing its function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist. It stimulates the production of cAMP, which can activate PKA. PKA then phosphorylates RSP3, enhancing its function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor. By inhibiting PDE4, it increases intracellular cAMP levels. The increased cAMP activates PKA, which can phosphorylate RSP3, enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels. The increased cAMP activates PKA, which phosphorylates RSP3, enhancing its function. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits phosphodiesterase-1, leading to increased cAMP levels. The elevated cAMP levels activate PKA, which phosphorylates RSP3, enhancing its function. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterases, increasing cAMP levels. The increased cAMP activates PKA, which phosphorylates RSP3, enhancing its function. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a phosphodiesterase-3 inhibitor that leads to increased cAMP levels. The elevated cAMP levels activate PKA, which phosphorylates RSP3, enhancing its function. | ||||||
Pentoxifylline | 6493-05-6 | sc-203184 | 1 g | $20.00 | 3 | |
Pentoxyfylline inhibits phosphodiesterases, leading to increased cAMP levels. The increased cAMP activates PKA, which phosphorylates RSP3, enhancing its function. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline is a non-specific inhibitor of phosphodiesterases, increasing cAMP levels. The increase in cAMP activates PKA, which phosphorylates RSP3, enhancing its function. | ||||||