RREB1 Inhibitors
RREB1 inhibitors belong to a distinctive chemical class that specifically targets the Repressor Element 1-Silencing Transcription Factor (REST) corepressor 1 (CoREST) Binding protein 1 (RREB1). RREB1, also known as Ras Responsive Element Binding Protein 1, is a transcription factor that plays a crucial role in regulating gene expression. It is involved in various cellular processes, including cell proliferation, differentiation, and survival. The inhibitors designed for RREB1 act by modulating its activity, either by impeding its binding to specific DNA sequences or by disrupting its interaction with other cellular components.
RREB1 inhibitors exhibit a diverse array of chemical scaffolds, reflecting the multifaceted nature of their binding interactions with the target protein. Researchers have explored small molecules as well as biologics as potential RREB1 inhibitors, each with unique mechanisms of action. The development of these inhibitors has been driven by the need to better understand the regulatory networks controlled by RREB1 and to explore potential applications in various biological contexts. Furthermore, ongoing studies aim to elucidate the structural determinants governing the specificity of RREB1 inhibitors, paving the way for the rational design of novel compounds with enhanced potency and selectivity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
Selumetinib is a MEK1/2 inhibitor. It can indirectly inhibit RREB1 by blocking the RAS/RAF/MEK/ERK pathway, thus preventing the downstream activation of RREB1. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Trametinib is another MEK1/2 inhibitor. It can disrupt RREB1 activity by inhibiting the RAS/RAF/MEK/ERK pathway. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib is a multi-kinase inhibitor that targets RAF kinases. By inhibiting RAF, it indirectly suppresses the activation of RREB1 via the RAS/RAF/MEK/ERK pathway. | ||||||
Vemurafenib | 918504-65-1 | sc-364643 sc-364643A | 10 mg 50 mg | $117.00 $423.00 | 11 | |
Vemurafenib inhibits BRAF, a protein in the RAS signaling pathway. This disrupts downstream signaling, including RREB1 activation. | ||||||
Dabrafenib | 1195765-45-7 | sc-364477 sc-364477A sc-364477B sc-364477C sc-364477D | 5 mg 25 mg 50 mg 100 mg 10 g | $141.00 $260.00 $278.00 $411.00 $12485.00 | 6 | |
Dabrafenib is a BRAF inhibitor. It can indirectly inhibit RREB1 through the RAS/RAF/MEK/ERK pathway. | ||||||
Linsitinib | 867160-71-2 | sc-396762 sc-396762A | 5 mg 10 mg | $146.00 $265.00 | 1 | |
Linsitinib is an IGF-1R inhibitor. It can indirectly inhibit RREB1 by blocking IGF-1R, which can modulate RAS signaling. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Nilotinib is a tyrosine kinase inhibitor that can have an indirect effect on RREB1 by modulating pathways that cooperate with RAS signaling. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $197.00 $520.00 $1093.00 | 4 | |
Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor. It can indirectly influence RREB1 by modulating pathways that interact with RAS signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor. It can indirectly inhibit RREB1 by affecting protein degradation, including proteins in the RAS pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. It can indirectly inhibit RREB1 by blocking PI3K/AKT signaling, which can interact with RAS signaling. | ||||||