Rock-2 Inhibitors
Items 11 to 15 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fasudil dihydrochloride | 203911-27-7 | sc-358231 sc-358231A | 10 mg 100 mg | $117.00 $306.00 | 4 | |
Fasudil dihydrochloride serves as a selective inhibitor of ROCK-2, demonstrating a unique affinity for the enzyme's binding pocket. This compound engages in specific hydrogen bonding and hydrophobic interactions, stabilizing a distinct conformation that disrupts downstream signaling pathways. Its solubility profile allows for effective diffusion across cellular membranes, while its influence on actin filament dynamics contributes to alterations in cellular morphology and motility. | ||||||
CAY10622 | 1038549-25-5 | sc-358882 sc-358882A | 1 mg 5 mg | $95.00 $350.00 | ||
CAY10622 acts as a selective inhibitor of ROCK-2, characterized by its ability to form strong electrostatic interactions with key residues in the enzyme's active site. This compound exhibits unique kinetic properties, leading to a rapid onset of inhibition that alters the enzyme's conformational dynamics. Its distinct hydrophilic and lipophilic balance enhances membrane permeability, facilitating targeted cellular uptake and influencing cytoskeletal organization through modulation of RhoA signaling pathways. | ||||||
RKI-1447 | 1342278-01-6 | sc-472590 | 1 mg | $330.00 | ||
RKI-1447 is a small-molecule ROCK-2 inhibitor that has shown potential in inhibiting cancer cell invasion and metastasis. It is being investigated as an anticancer agent. | ||||||
GSK 429286 | 864082-47-3 | sc-361200 sc-361200B sc-361200A | 1 mg 5 mg 10 mg | $39.00 $123.00 $230.00 | ||
GSK429286A is a highly selective ROCK-2 inhibitor that has shown efficacy in reducing cardiac hypertrophy and fibrosis in research models of heart disease. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $102.00 $357.00 | 7 | |
H-1152 is a ROCK-2 inhibitor that has been studied for its potential use in ischemic stroke and neurodegenerative diseases due to its neuroprotective properties. This has only been tested in research only. | ||||||