CAY10622 CAS: 1038549-25-5
MF: C25H25N5O3
MW: 443.5
A potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases.

CAY10622 (CAS 1038549-25-5)

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Alternate Names: 3- [[[[[4- (aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]- N- (1, 2, 3, 4- tetrahydro- 7- isoquinolinyl)- benzamide
Application: CAY10622 is CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases
CAS Number: 1038549-25-5
Molecular Weight: 443.5
Molecular Formula: C25H25N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. It is inactive against an additional 44 kinases. ROCK-I and ROCK-II act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewa


References

1. Watanabe, K., et al. 2007. Nat. Biotechnol. 25: 681-686. PMID: 17529971
2. Olson, M.F. 2008. Curr. Opin. Cell Biol. 20: 242-248. PMID: 18282695
3. Narumiya, S., et al. 2009. Cancer Metastasis Rev. 28: 65-76. PMID: 19160018
4. Morwick, T., et al. 2010. J. Med. Chem. 53: 759-777. PMID: 20000469

Physical State :
Solid
Storage :
Store at -20° C
Boiling Point :
628.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44819541
SMILES :
C1CNCC2=C1C=CC(=C2)NC(=O)C3=CC(=CC=C3)CNC(=O)NC4=CC=C(C=C4)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

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