RNF184 Inhibitors
RNF184, an E3 ubiquitin-protein ligase, partakes in the complex regulation of protein ubiquitination and degradation. The inhibitors presented influence several junctures in the protein degradation process and, while not direct inhibitors of RNF184, they provide a glimpse into how RNF184's function can be modulated. For instance, MG132 and Lactacystin, as proteasome inhibitors, obstruct the final stages of the ubiquitin-proteasome pathway. By doing so, they can influence the overall ubiquitin landscape and the fate of proteins tagged by E3 ligases such as RNF184. Further upstream, PYR-41 targets the E1 ubiquitin-activating enzyme, and its inhibition can echo downstream to RNF184's function by impeding the initiation of the ubiquitination cascade.
MLN4924, which inhibits the NEDD8-activating enzyme, presents an interesting angle as it hampers cullin-RING ligases, a subclass of E3 ligases. It highlights the broad spectrum of ubiquitination and its intricate regulation. Another intriguing facet of protein regulation is autophagy, a catabolic process where cells devour their own components. Compounds like Chloroquine and 3-Methyladenine, by disrupting autophagy, can cast an indirect influence on the fate of ubiquitinated proteins and the broader impact of E3 ligases like RNF184.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially affecting RNF184-mediated protein degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Irreversible proteasome inhibitor, can disrupt the degradation of proteins ubiquitinated by E3 ligases like RNF184. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Inhibitor of NEDD8-activating enzyme, blocks cullin-RING ligases, potentially influencing ubiquitination events involving RNF184. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
E1 ubiquitin-activating enzyme inhibitor, impeding the first step of the ubiquitination cascade and potentially affecting RNF184's role. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Autophagy inhibitor, can affect protein turnover and the downstream consequences of RNF184's ubiquitination activities. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
V-ATPase inhibitor, interferes with lysosomal acidification and autophagy, potentially modulating outcomes of RNF184-mediated ubiquitination. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2-p53 interaction inhibitor, can affect ubiquitination and degradation of p53, a process that might be influenced if RNF184 has roles in this pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor, prevents the breakdown of ubiquitinated proteins, potentially modulating proteins tagged by RNF184. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
ATM kinase inhibitor, can influence DNA damage response and associated ubiquitination events, offering indirect modulation of RNF184's potential roles. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Potent proteasome inhibitor, interferes with the degradation of ubiquitinated proteins, potentially affecting RNF184's function. | ||||||