RGMa Inhibitors
RGMa inhibitors belong to a distinct chemical class that has garnered considerable attention in the realm of neuroscience and neuroregeneration research. These compounds are primarily characterized by their ability to target and modulate the activity of RGMa, which stands for Repulsive Guidance Molecule A. RGMa is a protein that plays a pivotal role in the central nervous system (CNS) by exerting inhibitory effects on axonal growth and neural plasticity. Its presence in the CNS has been associated with of axonal regeneration and neurite outgrowth, making it a critical factor in processes like neuronal development, injury response, and synaptic plasticity.
RGMa inhibitors typically encompasses a range of small molecules and biologics that have been designed to interfere with RGMa's inhibitory signaling pathways. These compounds work by binding to RGMa or its receptors, thereby blocking the downstream inhibitory signals and promoting neural growth and regeneration. RGMa inhibitors have shown promise in studies and animal models for their potential to enhance axonal regeneration, improve functional recovery after neurological injuries, and potentially neurodegenerative conditions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Bone morphogenetic protein-2 (BMP-2) can enhance the signaling of BMP receptors, potentially reducing RGMa-mediated inhibition of axonal growth by promoting regenerative pathways. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide is an integrin inhibitor that targets αvβ3 and αvβ5 integrins. It can disrupt the interaction between RGMa and its neuronal receptor Neogenin, which utilizes integrins for signaling. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
DMH1 is a selective BMP receptor inhibitor that can modulate BMP signaling, which is intertwined with RGMa function, potentially reducing its inhibitory effects. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 inhibits the activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7, which can modify TGF-β signaling and indirectly affect the downstream effects of RGMa. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Dorsomorphin is an inhibitor of BMP signaling and can suppress the phosphorylation of Smads, which might indirectly diminish RGMa effects that rely on BMP signaling. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 is a potent inhibitor of Rho-associated protein kinase (ROCK), which can alter cytoskeletal dynamics and potentially influence RGMa-mediated cellular processes. | ||||||