RFX7 Activators
RFX7 activators are a diverse set of compounds that indirectly promote the functional activity of RFX7 via distinct signaling pathways. Forskolin, by increasing intracellular cAMP, indirectly augments RFX7 activity through the activation of PKA, which may phosphorylate proteins that enhance RFX7's ability to regulate gene expression. Similarly, 3-Isobutyl-1-methylxanthine (IBMX) and its analog, Dibutyryl-cAMP, prevent cAMP degradation and mimic its action respectively, thereby sustaining PKA activation and promoting RFX7-enhanced transcriptional regulation. EGCG, a polyphenol, inhibits multiple protein kinases, which could reduce negative regulatory effects on RFX7, indirectly sustaining its transcriptional activity.
Furthermore, Sildenafil citrate, through its inhibition of PDE5 and subsequent rise in cAMP and cGMP levels, could provide another route to enhance RFX7 function by engaging PKA or PKG signaling pathways. These RFX7 activators operate through a network of intracellular signaling modifications that converge on the enhancement of RFX7, leading to a more proficient execution of its gene regulatory functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels in the cell. Elevated cAMP activates PKA, which can phosphorylate various proteins that may interact with RFX7, enhancing RFX7's transcriptional activity on target genes. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
This xanthine derivative inhibits phosphodiesterases, leading to increased cAMP levels that activate PKA. PKA can then enhance RFX7 activity by phosphorylating associated proteins that regulate RFX7's DNA-binding capacity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that is resistant to degradation by phosphodiesterases, directly activating PKA. Activation of PKA by Dibutyryl-cAMP can promote the phosphorylation of proteins that indirectly enhance the activity of RFX7. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A catechin found in green tea, EGCG inhibits various protein kinases, potentially altering signaling pathways that modulate RFX7 activity, thereby enhancing RFX7-mediated gene transcription indirectly. | ||||||