RFPL4A Activators
RFPL4A activators are a diverse group of chemicals that can enhance the activity of the RFPL4A protein. These chemicals can achieve this activation through various mechanisms, including inhibiting kinases that negatively regulate RFPL4A activity, elevating the levels of signaling molecules that activate RFPL4A, and suppressing signaling pathways that hinder RFPL4A activity.
Several chemicals directly inhibit kinases that negatively regulate RFPL4A activity, such as lithium chloride, forskolin, and staurosporine. Lithium chloride specifically inhibits the GSK3β kinase, a known negative regulator of RFPL4A activity. Forskolin, on the other hand, increases the levels of cyclic AMP (cAMP), a second messenger that can activate various signaling pathways, including the RFPL4A activation pathway. Similarly, staurosporine directly inhibits the PKC kinase, another negative regulator of RFPL4A activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride (LiCl) is a salt that has been shown to activate RFPL4A in a variety of cell types. LiCl can activate RFPL4A by inhibiting the GSK3β kinase, which is a negative regulator of RFPL4A activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that has been shown to activate RFPL4A in a variety of cell types. Forskolin can activate RFPL4A by increasing the levels of cyclic AMP (cAMP), which is a second messenger that can activate a variety of signaling pathways, including the RFPL4A activation pathway. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a serine/threonine kinase inhibitor that has been shown to activate RFPL4A in a variety of cell types. Staurosporine can activate RFPL4A by inhibiting the PKC kinase, which is a negative regulator of RFPL4A activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphatidylinositol 3-kinase (PI3K) inhibitor that has been shown to activate RFPL4A in a variety of cell types. Wortmannin can activate RFPL4A by inhibiting the PI3K signaling pathway, which can lead to the activation of the MAPK signaling pathway, which in turn activates RFPL4A. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a mammalian target of rapamycin (mTOR) inhibitor that has been shown to activate RFPL4A in a variety of cell types. Rapamycin can activate RFPL4A by inhibiting the mTOR signaling pathway, which can lead to the activation of the AMPK signaling pathway, which in turn activates RFPL4A. | ||||||