resistin Activators
Resistin activators comprise a diverse class of compounds that exert their activating effects on resistin through specific and intricate cellular pathways. These chemicals target various signaling cascades, illustrating the complexity of resistin regulation at the molecular level. Dihydrocapsaicin, for instance, activates resistin by modulating the transient receptor potential vanilloid 1 (TRPV1) channel, leading to calcium influx and downstream activation of resistin expression. GW501516, a peroxisome proliferator-activated receptor-delta (PPAR-δ) agonist, directly activates resistin by binding to PPAR-δ, illustrating a direct molecular mechanism for promoting resistin transcription. Oleic acid, through its action on peroxisome proliferator-activated receptor-alpha (PPAR-α), showcases the interplay between fatty acid metabolism and resistin regulation. Roflumilast, a phosphodiesterase 4 (PDE4) inhibitor, indirectly activates resistin by modulating cyclic adenosine monophosphate (cAMP) levels and activating protein kinase A (PKA).
Lycopene, forskolin, 4-Hydroxyderricin, and naringenin activate resistin through modulation of various pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2), cAMP/PKA, NF-κB, and PPAR-γ, respectively, emphasizing the specificity of their actions on resistin regulation. Troglitazone, GSK4716, and fisetin directly activate resistin by acting as agonists for peroxisome proliferator-activated receptors (PPAR-γ and PPAR-β/δ) or modulating the mitogen-activated protein kinase (MAPK) pathway. The detailed understanding of these resistin activators sheds light on the diverse array of pathways that can be targeted to enhance resistin expression. This chemical class contributes to unraveling the complexities of resistin regulation, providing valuable insights into potential molecular interventions that can modulate resistin levels in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dihydrocapsaicin | 19408-84-5 | sc-202578 sc-202578A | 10 mg 50 mg | $51.00 $153.00 | 1 | |
Dihydrocapsaicin activates resistin by modulating the transient receptor potential vanilloid 1 (TRPV1) channel. As a capsaicinoid, dihydrocapsaicin stimulates TRPV1, leading to calcium influx. This calcium signaling event activates downstream pathways that positively influence resistin expression, providing a direct means of activating resistin through the TRPV1-mediated pathway. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, a peroxisome proliferator-activated receptor-delta (PPAR-δ) agonist, directly activates resistin by binding to PPAR-δ. This activation of PPAR-δ leads to increased resistin gene transcription, illustrating a direct molecular mechanism through which GW501516 promotes resistin expression. The specific targeting of PPAR-δ highlights GW501516 as a direct activator, emphasizing its role in the modulation of resistin at the transcriptional level. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid activates resistin by influencing the peroxisome proliferator-activated receptor-alpha (PPAR-α) pathway. As a monounsaturated fatty acid, oleic acid stimulates PPAR-α, leading to increased resistin expression. The activation of PPAR-α by oleic acid provides a direct means of promoting resistin transcription, showcasing the interplay between fatty acid metabolism and resistin regulation. | ||||||
Roflumilast | 162401-32-3 | sc-208313 | 5 mg | $59.00 | 21 | |
Roflumilast, a phosphodiesterase 4 (PDE4) inhibitor, indirectly activates resistin by modulating cyclic adenosine monophosphate (cAMP) levels. By inhibiting PDE4, roflumilast increases cAMP concentrations, which, in turn, activate protein kinase A (PKA). PKA activation positively influences resistin expression, providing an indirect means of activation through the cAMP/PKA signaling cascade. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $138.00 $540.00 | 5 | |
15-Deoxy-Delta(12,14)-prostaglandin J2 activates resistin by targeting the peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. As a natural prostaglandin derivative, it acts as a PPAR-γ agonist, promoting resistin gene transcription. The direct activation of PPAR-γ by 15-Deoxy-Delta(12,14)-prostaglandin J2 illustrates its role as a specific activator of resistin, emphasizing its impact on the molecular regulation of resistin expression. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene activates resistin by influencing the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. As a carotenoid, lycopene activates Nrf2, leading to increased resistin expression. The activation of Nrf2 by lycopene provides a direct means of promoting resistin transcription, showcasing the intricate connection between carotenoid metabolism and resistin regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates resistin by modulating adenylate cyclase and increasing cyclic adenosine monophosphate (cAMP) levels. This leads to the activation of protein kinase A (PKA), positively influencing resistin expression. The direct impact of forskolin on cAMP/PKA signaling provides a specific mechanism through which it activates resistin at the molecular level. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin activates resistin by influencing the peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. As a flavonoid, naringenin acts as a PPAR-γ agonist, promoting resistin gene transcription. The direct activation of PPAR-γ by naringenin illustrates its role as a specific activator of resistin, emphasizing its impact on the molecular regulation of resistin expression. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone, a thiazolidinedione class drug, directly activates resistin by acting as a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist. Its binding to PPAR-γ leads to increased resistin expression, providing a direct means of activating resistin at the transcriptional level. The specific targeting of PPAR-γ by troglitazone underscores its role as a direct activator, illustrating its impact on resistin regulation through molecular pathways. | ||||||
GSK 4716 | 101574-65-6 | sc-203986 sc-203986A | 10 mg 50 mg | $71.00 $285.00 | ||
GSK 4716, a peroxisome proliferator-activated receptor-beta/delta (PPAR-β/δ) agonist, directly activates resistin by binding to PPAR-β/δ. This activation of PPAR-β/δ leads to increased resistin gene transcription, showcasing a direct molecular mechanism through which GSK4716 promotes resistin expression. The specific targeting of PPAR-β/δ highlights GSK4716 as a direct activator, emphasizing its role in the modulation of resistin at the transcriptional level. | ||||||