resistin Inhibitors
Resistin inhibitors form a diverse class of compounds that exert their inhibitory effects on resistin through intricate cellular pathways. These compounds target specific signaling cascades, illustrating the complexity of resistin regulation at the molecular level. AMP-activated protein kinase (AMPK) activators, such as AICAR and metformin, indirectly inhibit resistin by modulating cellular energy homeostasis, showcasing the interconnectedness of metabolic pathways with resistin expression. Thiazolidinedione class drugs like rosiglitazone directly inhibit resistin by acting as peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists, influencing resistin gene transcription.
Natural compounds like berberine, quercetin, and ursolic acid showcase indirect inhibition by targeting the nuclear factor-kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and phosphoinositide 3-kinase (PI3K)/Akt pathways, respectively. Synthetic inhibitors like GW9662, SB203580, and Compound C provide direct inhibition by selectively targeting PPAR-γ, p38 mitogen-activated protein kinase (MAPK), and AMPK, emphasizing the specificity of their actions on resistin regulation. Furthermore, compounds like salicylic acid and dimethyl fumarate showcase indirect inhibition by modulating the mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, respectively. The detailed understanding of these resistin inhibitors highlights the intricate network of cellular pathways that can be modulated to influence resistin expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator that indirectly inhibits resistin. By stimulating AMPK, AICAR modulates cellular energy status, leading to downstream effects on resistin expression and secretion. The AMPK pathway intersects with resistin regulation, influencing its levels through indirect cellular energy-related mechanisms. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a thiazolidinedione class drug that acts as a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist. Its impact on resistin is mediated through PPAR-γ, which regulates resistin gene expression. By binding to PPAR-γ, rosiglitazone can downregulate resistin production, providing a direct means of inhibiting resistin at the transcriptional level. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine influences resistin expression by inhibiting the nuclear factor-kappa B (NF-κB) pathway. As an alkaloid, berberine modulates the activity of NF-κB, a key regulator of resistin gene transcription. Through this mechanism, berberine disrupts the signaling cascade that leads to resistin synthesis, serving as an indirect inhibitor through its impact on the NF-κB pathway. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin, an AMPK activator, influences resistin levels by regulating cellular energy homeostasis. Its activation of AMPK leads to downstream effects on resistin expression, providing an indirect inhibitory effect. Metformin's impact on resistin is intricately tied to its role in cellular metabolism, illustrating how metabolic pathways intersect with resistin regulation. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid, an anti-inflammatory compound, indirectly inhibits resistin by modulating the mitogen-activated protein kinase (MAPK) pathway. By interfering with MAPK signaling, salicylic acid disrupts the pathways influencing resistin production, illustrating a connection between inflammatory signaling and resistin regulation. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol is a natural polyphenol that acts as a sirtuin 1 (SIRT1) activator. Its inhibition of resistin is mediated through SIRT1, which influences resistin expression at the transcriptional level. By activating SIRT1, piceatannol provides a direct means of inhibiting resistin synthesis, showcasing the intricate relationship between sirtuins and resistin regulation. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW9662 is a selective peroxisome proliferator-activated receptor-gamma (PPAR-γ) antagonist. By blocking PPAR-γ, GW9662 disrupts the transcriptional regulation of resistin, leading to decreased resistin production. The specific antagonistic action of GW9662 on PPAR-γ underscores its role as a direct inhibitor of resistin at the molecular level. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, inhibits resistin by modulating the c-Jun N-terminal kinase (JNK) pathway. Its impact on resistin is mediated through the JNK pathway, where quercetin acts as a negative regulator. By influencing JNK signaling, quercetin disrupts the pathways involved in resistin expression, providing an indirect means of inhibiting resistin through its modulation of the JNK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK). Its inhibition of resistin is mediated through the p38 MAPK pathway, where SB203580 disrupts the signaling cascade leading to resistin synthesis. The specific targeting of p38 MAPK highlights SB203580 as a direct inhibitor, illustrating the intricate connection between MAPK pathways and resistin regulation. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic acid influences resistin expression by modulating the phosphoinositide 3-kinase (PI3K)/Akt pathway. As a triterpenoid, ursolic acid disrupts the PI3K/Akt signaling cascade, leading to downstream effects on resistin levels. This provides an indirect means of inhibiting resistin through the modulation of the PI3K/Akt pathway, showcasing the interplay between cellular signaling and resistin regulation. | ||||||