Troglitazone CAS: 97322-87-7
MF: C24H27NO5S
MW: 441.5
A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent.

Troglitazone (CAS 97322-87-7)

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Applicazione: A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent
Numero CAS: 97322-87-7
Purezza: ≥98%
Peso molecolare: 441.5
Formula molecolare: C24H27NO5S
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Troglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest through hypophosphorylation of Rb (retinoblastoma) protein and an increase of the cyclin-dependent kinase inhibitors, p21 and p27 proteins. In addition, Troglitazone has been reported to have profound antioxidant and antiinflammatory effects, and found to suppress L-type and receptor operated Ca2+ channel and PKC (protein kinase C). Experiments have shown Troglitazone to bind and activate PPARγ(peroxisome proliferator-activated receptor γ). PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells.


Referenze

1. Tsubouchi, Y., et al. 2000. Biochem. Biophys. Res. Commun. 270: 400-405. PMID: 10753637
2. Okura, T., et al. 2000. Eur. J. Pharmacol. 407: 227-235. PMID: 11068018
3. Fujiwara, T., et al. 2000. Life Sci. 67: 2405-2416. PMID: 11065164
4. Aljada, A., et al. 2001. J. Clin. Endocrinol. Metab. 86: 3250-3256. PMID: 11443197
5. Berger, J., et al. 2002. Annu. Rev. Med. 53: 409-435. PMID: 11818483
6. Yoshizawa, K., et al. 2002. Cancer. 95: 2243-2251. PMID: 12412180

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (>25 mg/ml) at 50° C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSO:PBS (1:6, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25° C.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
312.54° C (Predicted)
Punto di ebollizione :
~657.0° C at 760 mmHg (Predicted)
Densità :
~1.3 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.61 (Predicted)
IC50 :
Stimulatin PPARγg glucose transport: EC5050 = 1 µM (adipocytes); PPARγ: EC5050 = 780 nM (murine); PPARγ: EC5050 = 555 nM (human); Induces cell cycle arrest and apoptosis: EC5050 = 10 µM (cancer cell lines); Monoamine oxidase B: IC50 = 2.07 µM (human)
Ki Data :
Peroxisome proliferator-activated receptor gamma: Ki= 3.8 µM (human)
Valori pK :
pKa: 6.35 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
RTECS :
XJ5813130
PubChem CID :
5591
Indice Merck :
14: 9769
Numero MDL :
MFCD00878416
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O

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Troglitazone  Citazioni prodotti

Vedi quanti altri hanno usato Troglitazone. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a5 di 5 totali

PMID: # 31416829  2019. Biochem. J. 476: 2427-2447.

PMID: # 26313919  Myneni, VD. et al. 2015. Cell death & disease. 6: e1868.

PMID: # 24910239  Penner, N. et al. 2014. Drug Metab Lett. 8: 36-42.

PMID: # 22981620  Kim, JA. et al. 2012. Toxicology letters. 214: 175-81.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

Ciatazioni 1 a5 di 5 totali
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