Rer1 Inhibitors
Chemical inhibitors of RER1 function through various mechanisms to disrupt the protein's role in the quality control of integral membrane proteins and the retrieval of endoplasmic reticulum (ER) resident proteins. Brefeldin A directly inhibits RER1 by dismantling the Golgi apparatus structure, which is crucial for RER1's operation. Monensin alters the pH within Golgi compartments, thereby affecting RER1's ability to sort and traffic proteins. Tunicamycin inhibits N-linked glycosylation, a process indirectly connected to RER1, leading to an accumulation of misfolded glycoproteins and increased ER stress that can overload RER1's functionality. Castanospermine and Deoxynojirimycin target glucosidases I and II, essential enzymes for glycoprotein folding. Their inhibition raises ER stress and may overwhelm RER1's capacity to maintain protein quality control, leading to its functional inhibition. Swainsonine impedes mannosidase II, affecting the processing of N-glycans in the Golgi and potentially overwhelming RER1's quality control system due to misfolded glycoproteins.
Kifunensine targets mannosidase I in the ER, creating a backlog in the protein quality control system, indirectly inhibiting RER1. The iminosugar derivative N-(n-Nonyl)deoxynojirimycin also inhibits glucosidases, leading to a buildup of unfolded or misfolded glycoproteins, stressing the ER and RER1's sorting role. Nocodazole and Colchicine disrupt microtubule dynamics, essential for intracellular trafficking, indirectly affecting RER1's function in protein sorting and retrieval. Cytochalasin D acts on actin polymerization, crucial for vesicle movement, potentially affecting RER1's associated trafficking processes. Lastly, Dynasore inhibits the GTPase dynamin, responsible for vesicle scission from membranes, which can lead to reduced vesicular trafficking, indirectly inhibiting RER1's function in protein sorting between the Golgi and ER. Each of these chemicals, by altering specific cellular mechanisms, can impede the function of RER1, highlighting its central role in cellular protein quality control and trafficking pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits RER1 by disrupting the Golgi apparatus structure and function, where RER1 is involved in the quality control of integral membrane proteins. This inhibition of the Golgi apparatus prevents RER1 from exerting its role in the retrieval of escaped endoplasmic reticulum (ER) resident proteins. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a polyether that disrupts Golgi function by altering the pH within Golgi compartments, leading to inhibition of RER1's ability to participate in the sorting and trafficking of proteins from the Golgi to the ER. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, a process RER1 is indirectly associated with by quality control of glycosylated proteins. This results in the accumulation of misfolded glycoproteins, which can indirectly inhibit RER1's function due to the heightened ER stress and unfolded protein response. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine inhibits glucosidases I and II, enzymes crucial for proper glycoprotein folding, thereby increasing ER stress and potentially overwhelming RER1's ability to maintain protein quality control, leading to its functional inhibition. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine inhibits mannosidase II, an enzyme involved in the processing of N-glycans in the Golgi, which can lead to misfolded glycoproteins and indirectly inhibit the function of RER1 by overwhelming the glycoprotein quality control system. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin inhibits alpha-glucosidases, which are involved in the trimming of glucose residues from N-linked glycoproteins; inhibition of this process can indirectly lead to the functional inhibition of RER1 by impairing its associated glycoprotein processing pathways. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $135.00 $540.00 $1025.00 $6248.00 | 25 | |
Kifunensine inhibits mannosidase I in the ER, leading to misfolded glycoproteins and indirectly inhibiting the function of RER1 by causing a backlog in the protein quality control system of the ER and Golgi. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can lead to a disturbance in intracellular trafficking and indirectly inhibit RER1's function in the sorting and trafficking of proteins between the Golgi and ER. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing microtubule assembly, which can indirectly inhibit RER1 by disrupting intracellular trafficking processes in which RER1 is involved, particularly the retrieval of proteins to the ER. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, which is essential for various cell processes, including vesicle movement; this can indirectly inhibit RER1 by affecting the trafficking of proteins that RER1 sorts and retrieves. | ||||||