Reg I Inhibitors
Chemical inhibitors of Reg I can exert their influence by targeting specific signaling pathways and enzymes that indirectly dictate the functional state of Reg I protein. Phosphoramidon, through its inhibition of Neutral Endopeptidase, can lead to increased levels of bioactive peptides, which could exert a negative feedback on Reg I protein activity. LY-294002 and Wortmannin, both phosphoinositide 3-kinase (PI3K) inhibitors, can suppress the PI3K/Akt pathway, leading to a decrease in survival signaling that is necessary for the optimal activity of Reg I protein. Another layer of regulation involves the MAPK signaling pathway where SB-203580, PD98059, U0126, and SP600125 can inhibit the activity of p38 MAPK, MEK1/2, and JNK, respectively. The inhibition of these kinases results in a reduced pro-survival and stress response signaling, thus decreasing the activity of Reg I protein. Genistein, with its ability to inhibit multiple tyrosine kinases, can also disrupt cell growth and survival signals that control Reg I protein activity.
The second paragraph continues to explore additional mechanisms by which chemical inhibitors can reduce Reg I protein activity. Rapamycin, an mTOR inhibitor, can suppress cell proliferation signals, which are vital for the functional contribution of Reg I in tissue regeneration. Y-27632 targets the Rho-associated protein kinase (ROCK), which plays a role in cytoskeleton organization and cell motility, processes that are important for the biological activities of Reg I protein. By inhibiting ROCK, Y-27632 can lead to an indirect inhibition of Reg I protein activity. PP2, an inhibitor of Src family kinases, can disrupt the activity of Src kinases that are part of cell survival and proliferation pathways, thereby inhibiting Reg I protein activity. Lastly, SN-38 inhibits topoisomerase I, leading to DNA damage and cell cycle arrest, which can inhibit the activity of Reg I protein by disrupting the cellular proliferation and survival pathways.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $195.00 $620.00 | 8 | |
Phosphoramidon inhibits the enzyme Neutral Endopeptidase (NEP), which is involved in the degradation of bioactive peptides. Since Reg I is implicated in tissue regeneration and inflammation, and NEP can modulate inflammatory responses, inhibition of NEP by Phosphoramidon can lead to an accumulation of peptides that may inhibit Reg I activity by competitive interaction or feedback mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY-294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Since Reg I is part of signaling pathways involving PI3K, inhibition of PI3K by LY-294002 can reduce Akt phosphorylation and downstream signaling, which can inhibit Reg I protein activity due to reduced survival signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 is a selective inhibitor of p38 MAPK. Reg I is known to be involved in pathways associated with cell proliferation and survival, which are regulated by p38 MAPK. By inhibiting p38 MAPK, SB-203580 can decrease Reg I protein activity indirectly through reduced pro-survival signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK1/2, which are upstream of ERK1/2 in the MAPK signaling pathway. As Reg I is involved in cellular stress responses modulated by the MAPK pathway, inhibiting MEK with PD98059 can lead to decreased ERK activation and thus inhibit Reg I protein activity through reduced cellular proliferation and survival signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), part of the MAPK pathway. By inhibiting JNK activity, this compound can decrease the signaling that may regulate Reg I activity, leading to its functional inhibition through impaired response to cellular stress and inflammation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, which operates in a similar fashion to LY-294002, by inhibiting the PI3K/Akt pathway. This action can lead to decreased Reg I protein activity by limiting the survival and proliferation signals that regulate its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which can inhibit numerous tyrosine kinases involved in the activation of several signaling pathways that regulate cell growth and survival, potentially leading to the inhibition of Reg I protein activity through decreased cellular proliferation and survival signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is crucial for cell growth and proliferation. As Reg I is associated with cellular regeneration processes, rapamycin can inhibit Reg I protein activity through suppression of mTOR signaling and subsequent cellular proliferation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2 like PD98059, and by the same mechanism of action, it can lead to decreased ERK activation, which may inhibit Reg I protein activity through reduced MAPK pathway signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK). By inhibiting ROCK, Y-27632 can affect cytoskeleton organization and cell motility, which are important for tissue regeneration, possibly leading to inhibition of Reg I protein activity through these pathways. | ||||||