RDH14 Inhibitors

RDH14 inhibitors, such as, Citral and Disulfiram can reduce the availability of retinoid substrates or alter their metabolism, which can in turn affect the catalytic role of RDH14. Isotretinoin and Tretinoin, being retinoic acid analogs, can modulate the feedback mechanisms that control retinoid synthesis and degradation. This modulation can alter the balance of retinoid intermediates and end products, indirectly influencing RDH14's function. Flufenamic acid and Genistein have the capacity to interfere with retinoid signaling, which is intricately linked to the enzyme's activity.

Compounds such as Ketoconazole and Omeprazole, known to inhibit cytochrome P450 enzymes, can disrupt the broader retinoid metabolism network, thereby influencing RDH14 activity. Bisphenol A and Nitrofen, by disrupting endocrine function and retinoid signaling respectively, can lead to an indirect reduction in RDH14 activity. Lastly, Methotrexate and Aminoglutethimide, which affect dihydrofolate reductase and steroidogenesis, can also influence retinoid synthesis and metabolism, potentially altering the activity of RDH14.