RDH13 Activators
RDH13 Activators encompass a spectrum of chemical entities that indirectly promote the activity of RDH13 by interacting with various components of cellular metabolism and signaling pathways. The activators such as All-trans-retinoic acid and β-carotene engage with retinoid processing, either bybinding to nuclear receptors to modulate gene expression related to retinoid metabolism or by serving as precursors to retinal, the substrate of RDH13. This increased turnover of retinoids necessitates enhanced RDH13 activity to maintain homeostasis. Similarly, compounds like Citral and Retinol directly affect the substrate availability for RDH13, Citral by influencing the aldehyde balance and Retinol by being a direct substrate. On the other hand, cofactors and cellular environment modulators such as NAD+, Zinc, and α-Lipoic acid amplify RDH13's catalytic efficiency. NAD+ is crucial as a cofactor in the dehydrogenase reaction catalyzed by RDH13, Zinc may act as a structural stabilizer, and α-Lipoic acid contributes to the antioxidant defense, preserving RDH13's activity.
The functional enhancement of RDH13 is further supported by compounds that influence the cellular redox state, such as Resveratrol, Quercetin, and Sulforaphane. Resveratrol and Quercetin act on the NAD+/NADH ratio, a critical determinant of dehydrogenase enzymes' activity, including RDH13. Sulforaphane's activation of Nrf2 leads to an upregulation of antioxidant pathways, potentially creating a more favorable environment for RDH13 activity. Antioxidants like Lutein and Astaxanthin provide a protective effect, shielding RDH13 from oxidative damage and ensuring sustained enzymatic function. Collectively, these RDH13 Activators, through targeted biochemical interactions and cellular effects, facilitate the enhancement of RDH13's role in retinoid metabolism without directly influencing its expression levels or requiring direct binding to the enzyme.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans-retinoic acid is a metabolite of vitamin A that binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs). This binding can affect the expression of genes involved in retinoid metabolism, thereby indirectly enhancing RDH13 activity by increasing the demand for its substrate or product. | ||||||
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $80.00 $351.00 $621.00 $12791.00 | 5 | |
β-carotene is a precursor of vitamin A. Upon cleavage, it forms retinal, a substrate for RDH13, thereby potentially increasing its activity by substrate availability. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, an aldehyde found in lemon grass oil, can modulate aldehyde dehydrogenase activity. This might lead to an altered aldehyde-retinol ratio, indirectly enhancing RDH13 activity by affecting substrate availability. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
Nicotinamide adenine dinucleotide (NAD+) is a cofactor for many dehydrogenases, including RDH13. Increasing cellular NAD+ levels can enhance RDH13 activity by providing the necessary cofactor for its enzymatic action. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol that can influence sirtuin activity and the cellular redox state. Through modulation of NAD+/NADH ratio, it could indirectly enhance RDH13 activity by affecting the enzyme's redox environment. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid known to modulate the activity of various enzymes involved in cellular redox balance. It could enhance RDH13 activity by optimizing the redox state that favors RDH13's catalytic action. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is an isothiocyanate from cruciferous vegetables that activates Nrf2, a transcription factor that induces the expression of antioxidant enzymes. This activation could lead to an improved cellular environment for RDH13 activity. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Retinol is the alcohol form of vitamin A and a direct substrate of RDH13, thus its presence in the cell directly increases the activity of RDH13 by providing substrate. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a trace element that can act as a cofactor for RDH enzymes. While not directly linked to RDH13, zinc may enhance its activity by stabilizing the enzyme structure and function. | ||||||
Xanthophyll | 127-40-2 | sc-220391 sc-220391A | 25 mg 100 mg | $250.00 $900.00 | 2 | |
Lutein, a xanthophyll and an antioxidant, could protect RDH13 from oxidative damage, thereby maintaining its functional state and enhancing its activity indirectly. | ||||||