RBM24 inhibitors belong to a distinctive chemical class characterized by their ability to modulate the activity of RNA-binding motif protein 24 (RBM24), a crucial regulator of post-transcriptional gene expression. RBM24 is a conserved RNA-binding protein known for its involvement in the regulation of alternative splicing, mRNA stability, and translation. In recent years, researchers have explored the development of small molecules designed to inhibit RBM24, aiming to dissect the intricate mechanisms underlying RNA processing and control gene expression at the post-transcriptional level.
RBM24 inhibitors are designed to interact with specific binding sites on the RBM24 protein, disrupting its ability to bind to target RNA molecules effectively. The development of these inhibitors often involves a detailed understanding of the structural features of both RBM24 and the inhibitor compounds. Researchers employ a variety of computational and experimental techniques, such as structure-based drug design and high-throughput screening, to identify and optimize small molecules with a high affinity for the target protein. The rationale behind inhibiting RBM24 lies in the potential to uncover novel insights into RNA processing mechanisms and identify opportunities by modulating gene expression patterns. This class of compounds represents a valuable tool in the arsenal of molecular biologists and biochemists, offering a means to probe the intricacies of post-transcriptional gene regulation and paving the way for a deeper understanding of cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibits PI3K, a kinase that can modulate several downstream signaling pathways, potentially altering the cellular environment in which RBM24 functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, which may indirectly affect RBM24 activity by altering phosphorylation states of proteins within its regulatory network. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds to mTOR and inhibits its activity, which could lead to changes in mRNA translation and stability, processes in which RBM24 is implicated. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which is upstream of ERK in the MAPK pathway; ERK can influence transcription and splicing events relevant to RBM24. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that may disrupt downstream regulatory mechanisms of gene expression that involve RBM24. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which may affect transcriptional regulation and cellular stress responses linked to RBM24's role. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that can lead to changes in chromatin structure and gene expression, potentially affecting RBM24's RNA-binding activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can stabilize proteins and alter protein turnover, potentially impacting the protein network associated with RBM24. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor that influences DNA repair mechanisms; while not directly linked to RBM24, changes in DNA damage response can affect RNA processing. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $116.00 $330.00 $510.00 $816.00 $1632.00 | 10 | |
BCL-2 inhibitor that can influence apoptosis; by altering cell survival pathways, it may indirectly affect RBM24's role in RNA metabolism. | ||||||