RBM19 Inhibitors
Chemical inhibitors of RBM19 can exert their effects through various mechanisms that impede different aspects of cellular function. Paclitaxel, for instance, stabilizes microtubules and prevents their disassembly, affecting mitotic spindle formation and, consequently, cell cycle progression. This disruption can impact the function of RBM19, especially considering its role in nucleolar organization and ribosome biogenesis. Similarly, Camptothecin, by inhibiting Topoisomerase I, induces DNA damage during replication, which can influence RBM19's involvement in ribosomal RNA processing. Actinomycin D, known for its ability to bind to DNA at the transcription initiation complex, inhibits RNA elongation by RNA polymerase, thereby potentially affecting rRNA synthesis and, indirectly, RBM19's function in ribosome formation.
Aphidicolin, an inhibitor of DNA polymerases α and δ, halts DNA replication, which can disrupt cell cycle progression and indirectly inhibit the nucleolar activities of RBM19. Etoposide, which targets Topoisomerase II, leads to DNA strand breaks, potentially influencing RBM19's role due to the cellular response to DNA damage. Mitomycin C, by forming crosslinks within DNA, can also cause replication fork collapse, indirectly affecting RBM19's function in ribosome biogenesis. Brefeldin A disrupts transport between the endoplasmic reticulum and Golgi apparatus, leading to a loss of Golgi function, which can impede RBM19's role in ribosome assembly. Rocaglamide, by inhibiting eIF4A, can decrease protein synthesis demand, which may reflect on the necessity for RBM19's ribosome biogenesis activity. Cyclosporin A's inhibition of calcineurin affects NFAT, a transcription factor that regulates genes involved in ribosome biogenesis, with potential implications for RBM19. Rapamycin's inhibition of mTOR signaling, which is crucial for cell growth and ribosome biogenesis, can likewise affect RBM19's function. U0126, by inhibiting MEK1/2 and thus the MAPK/ERK pathway, can indirectly influence RBM19's role in ribosome production. Lastly, Leptomycin B targets the nuclear export of proteins by binding to exportin 1, which could result in the nuclear accumulation of ribosomal proteins and RNAs, disrupting RBM19's functions associated with ribosome biogenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and consequently inhibits their disassembly, disrupting mitotic spindle formation. This disruption can inhibit the cell cycle progression and impact the function of RBM19, which is known to be involved in nucleolar organization and ribosome biogenesis, processes that are tightly coupled to cell cycle progression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits Topoisomerase I, leading to DNA damage during replication. Given RBM19's involvement in ribosomal RNA processing, DNA damage can influence ribosome biogenesis indirectly, thereby inhibiting RBM19's functional role in the nucleolus. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to the DNA at the transcription initiation complex and prevents the elongation of RNA by RNA polymerase. This action can inhibit rRNA synthesis, indirectly impacting RBM19's role in ribosome biogenesis by limiting the rRNA substrate necessary for its function. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is an inhibitor of DNA polymerases α and δ, halting DNA replication. The inhibition of DNA replication can disrupt the cell cycle and indirectly inhibit the nucleolar activities of RBM19 due to reduced proliferation and altered nucleolar dynamics. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits Topoisomerase II, causing DNA strand breaks during replication. RBM19 is involved in ribosome biogenesis, which is sensitive to DNA damage and replication stress, potentially inhibiting RBM19's function due to the impaired cellular state. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C forms crosslinks in DNA, leading to replication fork collapse and DNA damage. Such genotoxic stress can indirectly inhibit the ribosome biogenesis function of RBM19 by disrupting the cell cycle and nucleolar integrity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts transport between the endoplasmic reticulum and Golgi apparatus, leading to a loss of Golgi function. This can inhibit the processing and modification of proteins and RNAs, indirectly impacting RBM19's role in ribosome assembly within the nucleolus. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Rocaglamide inhibits eukaryotic initiation factor 4A (eIF4A), an RNA helicase involved in mRNA translation initiation. Inhibiting eIF4A can result in decreased protein synthesis, which can indirectly inhibit RBM19 by reducing the demand for its ribosome biogenesis activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, leading to inhibition of the transcription factor NFAT. As NFAT can regulate genes involved in ribosome biogenesis, inhibiting NFAT can indirectly inhibit the nucleolar roles of RBM19, which is involved in this process. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and proliferation by sensing nutrient and energy levels. Inhibition of mTOR can lead to reduced ribosome biogenesis, thereby indirectly inhibiting RBM19's function associated with ribosome assembly and processing. | ||||||