RAMP1 Inhibitors
RAMP1 inhibitors belong to a class of chemical compounds that are designed to target and modulate the activity of the receptor activity-modifying protein 1 (RAMP1). RAMP1 is a key regulatory protein found in association with certain G-protein-coupled receptors (GPCRs), specifically those of the calcitonin receptor-like receptor (CLR) family. These receptors play a crucial role in regulating various physiological processes, including blood pressure regulation, vasodilation, and sensory perception. RAMP1, in particular, is known to interact with CLR to form the functional receptor complex that responds to calcitonin gene-related peptide (CGRP), a neuropeptide involved in pain transmission and vasodilation. Consequently, RAMP1 inhibitors are designed to modulate the activity of this complex, influencing the downstream signaling pathways that impact physiological responses mediated by CGRP.
The mechanism of action of RAMP1 inhibitors typically involves binding to RAMP1 and altering its interaction with CLR or other associated proteins. This modulation can result in changes in receptor conformation, affinity for ligands, or intracellular signaling cascades. By disrupting the normal functioning of the RAMP1-CLR complex, these inhibitors regulate the physiological processes mediated by CGRP and other ligands that interact with CLR family receptors. The development of RAMP1 inhibitors holds promise for gaining a better understanding of the role of CGRP and related pathways in various biological processes, as well as exploring avenues for interventions that may arise from this research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $54.00 $245.00 | 6 | |
Bexarotene, a retinoid X receptor agonist, could modify transcription factors that regulate RAMP1 gene expression, leading to a decrease in RAMP1 protein levels. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine chloride is known to inhibit protein kinase C (PKC), which might affect the PKC-mediated pathways that regulate the transcription and stability of RAMP1 mRNA. | ||||||
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $55.00 $98.00 | 9 | |
Tetrandrine might affect calcium channels and signaling pathways that are indirectly involved in the expression of RAMP1. | ||||||
WZ 4002 | 1213269-23-8 | sc-364655 sc-364655A | 10 mg 50 mg | $180.00 $744.00 | 1 | |
WZ4002 selectively inhibits EGFR mutants and may alter downstream signaling pathways, which could have a knock-on effect on the expression levels of RAMP1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that could disrupt PI3K/Akt signaling pathways, potentially downregulating transcription factors or stabilizing proteins that influence RAMP1 mRNA. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 inhibits Raf-1 kinase, which may lead to alterations in the MAPK/ERK signaling pathway and potentially decrease RAMP1 transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can lead to a broad range of effects on protein synthesis and gene expression, including potentially decreased expression of RAMP1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which may suppress downstream signaling involved in the regulation of RAMP1 gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor, which might alter the AP-1 transcription factor activity, possibly affecting RAMP1 gene expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that might modulate the expression of genes, including RAMP1, through interference with the p38 MAPK signaling pathway. | ||||||