Date published: 2025-12-18

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Raf-B Inhibitors

Raf-B inhibitors belong to a significant category of chemical compounds that play a pivotal role in modulating cellular signaling pathways. These inhibitors are specifically designed to target the activity of Raf-B, a kinase enzyme that is a part of the larger Raf family of kinases. Kinases are enzymes responsible for phosphorylating target proteins, thereby regulating various cellular processes. Raf-B, in particular, is implicated in pathways related to cell growth, proliferation, and differentiation. The development of Raf-B inhibitors stems from the recognition of its involvement in the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a fundamental role in transmitting extracellular signals to the nucleus, ultimately influencing gene expression. Structurally, Raf-B inhibitors exhibit distinct molecular arrangements that enable them to interact with the active site of the Raf-B enzyme. These compounds often possess a combination of hydrophobic and hydrogen-bonding moieties that facilitate their binding to specific residues within the enzyme's active pocket. This interaction effectively disrupts the enzymatic activity of Raf-B, leading to downstream effects on the MAPK pathway. Researchers have harnessed the insights gained from studying Raf-B inhibitors to gain a deeper understanding of intracellular communication networks and their impact on cellular behavior. By manipulating the activity of Raf-B through these inhibitors, scientists have unlocked valuable information about the intricate interplay between various signaling cascades. In summary, Raf-B inhibitors constitute a significant class of compounds with the capacity to modulate the activity of the Raf-B kinase enzyme. Through their targeted interaction with the enzyme's active site, these inhibitors provide a valuable tool for investigating cellular signaling pathways and the broader mechanisms that govern cellular responses to extracellular cues.

Items 1 to 10 of 17 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Blocks RAF kinases, interrupting the MAPK and angiogenesis pathways in cancer.

Raf Kinase Inhibitor V

918505-84-7sc-222241
sc-222241A
1 mg
10 mg
$198.00
$480.00
2
(2)

Raf Kinase Inhibitor V (CAS 918505-84-7) is a compound that functions as an inhibitor of Raf-B, a protein involved in cellular signaling pathways. It modulates specific biochemical processes and has relevance in research contexts.

Dabrafenib

1195765-45-7sc-364477
sc-364477A
sc-364477B
sc-364477C
sc-364477D
5 mg
25 mg
50 mg
100 mg
10 g
$138.00
$255.00
$273.00
$403.00
$12240.00
6
(1)

Selectively inhibits mutated BRAF proteins, disrupting the MAPK pathway in cancer cells.

AZ628

878739-06-1sc-364418
5 mg
$230.00
3
(0)

AZ628 (CAS 878739-06-1) is a chemical compound known for its role as an inhibitor of Raf-B, a protein involved in cell signaling pathways. It exerts its influence by targeting the Raf-B protein, impacting cellular processes. The compound's mechanism of action makes it significant for research in signal transduction pathways.

SB 590885

405554-55-4sc-363287
sc-363287A
10 mg
50 mg
$219.00
$924.00
(0)

SB 590885 (CAS 405554-55-4) is a chemical compound known for its role as a Raf-B inhibitor. It modulates the activity of Raf-B, a protein involved in cellular signaling pathways. By interacting with Raf-B, SB 590885 influences downstream cellular responses.

GDC-0879

905281-76-7sc-364497
5 mg
$225.00
(0)

GDC-0879 (CAS 905281-76-7) is a chemical compound known for its role as a Raf-B inhibitor, affecting specific cellular pathways.

Encorafenib

1269440-17-6sc-507422
1 mg
$115.00
(0)

Targets BRAF V600E and V600K mutants, leading to inhibition of cell proliferation.

Dabrafenib-D9

1423119-98-5sc-397070
1 mg
$618.00
(0)

Dabrafenib-D9, identified by CAS number 1423119-98-5, is a chemical compound known for its role as a potent inhibitor of Raf-B. It functions by modulating certain cellular pathways.

RAF265

927880-90-8sc-364599
5 mg
$191.00
(0)

RAF265 (CAS 927880-90-8) is a chemical compound known for its role as a potent inhibitor of Raf-B. It exerts its action by targeting specific pathways, thereby affecting cellular processes. The compound's interaction with Raf-B has attracted interest due to its potential impact on relevant signaling cascades.

Sorafenib Tosylate

475207-59-1sc-357801
sc-357801A
100 mg
1 g
$102.00
$306.00
16
(1)

Sorafenib Tosylate (CAS 475207-59-1) is a chemical compound known for its role as a potent inhibitor of Raf-B. It modulates the activity of this specific protein, which plays a crucial part in certain cellular pathways. This modulation has been of interest due to its impact on cellular processes, but its broader implications remain a subject of ongoing research.