Molecular structure of Raf Kinase Inhibitor V, CAS Number: 918505-84-7
Raf Kinase Inhibitor V (CAS 918505-84-7)
See product citations (2)
Alternate Names:
PLX-4720
Application:
Raf Kinase Inhibitor V is an inhibitor of Raf kinase
CAS Number:
918505-84-7
Purity:
≥95%
Molecular Weight:
413.83
Molecular Formula:
C17H14ClF2N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable azaindole compound that acts as a potent, ATP-site targeting and reversible inhibitor of Raf kinase with excellent selectivity over 64-other kinases. Shown to block ERK phosphorylation, induce cell cycle arrest and apoptosis in several B-RafV600E melanoma cells.
Raf Kinase Inhibitor V (CAS 918505-84-7) References
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. | Tsai, J., et al. 2008. Proc Natl Acad Sci U S A. 105: 3041-6. PMID: 18287029
- A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus. | Yin, R., et al. 2016. Antiviral Res. 133: 140-4. PMID: 27498149
- High levels of chromosomal instability facilitate the tumor growth and sphere formation. | Iemura, K., et al. 2022. Cancer Sci. 113: 2727-2737. PMID: 35662350
Inhibitor of:
Brk, Raf-1, Raf-B, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Raf Kinase Inhibitor V, 1 mg | sc-222241 | 1 mg | $198.00 | |||
Raf Kinase Inhibitor V, 10 mg | sc-222241A | 10 mg | $480.00 |