Date published: 2025-10-18

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Quenchers

Santa Cruz Biotechnology now offers a broad range of quenchers for use in various applications. Quenchers are specialized chemical compounds that play a crucial role in fluorescence-based assays and other biochemical experiments by absorbing fluorescence emitted by reporter molecules. This category of chemicals is essential in scientific research, particularly in the fields of molecular biology, genomics, and proteomics, where precise measurement and control of fluorescence signals are necessary. Quenchers are used to reduce background fluorescence, thereby enhancing the accuracy and sensitivity of quantitative assays, such as real-time PCR, FRET (Frster Resonance Energy Transfer) assays, and DNA sequencing. These compounds enable researchers to monitor biochemical processes in real-time, offering invaluable insights into molecular interactions and dynamic changes within cells. The ability to modulate fluorescence signals with quenchers has made them indispensable tools in the study of gene expression, protein-protein interactions, and the elucidation of complex biological pathways. As a result, quenchers are a fundamental component in advancing scientific knowledge and technological innovations in various research domains. View detailed information on our available quenchers by clicking on the product name.

Items 51 to 60 of 62 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DABCYL C2 amine

sc-460795
100 mg
$255.00
(0)

DABCYL C2 amine is a potent quencher characterized by its unique ability to disrupt fluorescence through non-radiative energy transfer. Its structure allows for effective interactions with excited-state fluorophores, leading to a significant reduction in emitted light. The compound exhibits rapid kinetics in quenching processes, making it ideal for real-time monitoring of molecular interactions. Its distinct amine functionality enhances compatibility with various labeling strategies, enabling precise control over fluorescence dynamics.

DNP-X acid, SE

82321-04-8sc-460801
25 mg
$120.00
(0)

DNP-X acid, SE serves as an effective quencher by engaging in specific molecular interactions that facilitate energy dissipation. Its unique structure promotes strong non-covalent interactions with excited fluorophores, leading to efficient energy transfer pathways that diminish fluorescence intensity. The compound's distinctive reactivity profile allows for rapid quenching kinetics, making it suitable for dynamic studies of molecular behavior. Additionally, its physical properties enhance its versatility in various experimental setups.

DNP amine

sc-460802
25 mg
$245.00
(0)

DNP amine functions as a potent quencher through its ability to form transient complexes with excited-state molecules, effectively interrupting their fluorescence. The compound's electron-rich amine groups engage in charge transfer interactions, which significantly alter the excited-state dynamics. This results in a rapid decrease in fluorescence intensity, driven by its unique steric and electronic properties. Its high solubility and stability further contribute to its effectiveness in diverse experimental conditions.

DABSYL chloride

56512-49-3sc-460805
1 g
$122.00
(0)

DABSYL chloride acts as an effective quencher by facilitating non-radiative energy transfer processes. Its unique structure allows for strong π-π stacking interactions with excited-state fluorophores, leading to enhanced deactivation pathways. The presence of the sulfonyl group enhances its electron-withdrawing capacity, promoting rapid electron transfer. This compound's high reactivity and ability to form stable adducts with various substrates make it a versatile tool in photophysical studies.

Tide Quencher™ 1 alkyne [TQ1 alkyne]

sc-460806
5 mg
$245.00
(0)

Tide Quencher™ 1 alkyne (TQ1 alkyne) serves as a potent quencher through its distinctive alkyne functionality, which promotes efficient energy dissipation via vibrational relaxation. Its linear structure facilitates unique steric interactions, allowing for selective quenching of excited states. The compound's ability to engage in rapid electron transfer processes enhances its quenching efficiency, making it a valuable component in studies of photochemical dynamics and reaction kinetics.

Tide Quencher™ 2 azide [TQ2 azide]

sc-460808
5 mg
$245.00
(0)

Tide Quencher™ 2 azide (TQ2 azide) exhibits remarkable quenching capabilities through its azide group, which enables effective energy transfer mechanisms. The compound's unique electronic configuration allows for strong interactions with excited states, facilitating non-radiative decay pathways. Its ability to stabilize transient species enhances reaction kinetics, making it an intriguing subject for investigations into photophysical processes and molecular dynamics.

Tide Quencher™ 2 alkyne [TQ2 alkyne]

sc-460811
5 mg
$245.00
(0)

Tide Quencher™ 2 alkyne (TQ2 alkyne) stands out as a potent quencher due to its alkyne moiety, which promotes unique π-π stacking interactions with nearby chromophores. This structural feature enhances energy dissipation through efficient vibrational relaxation pathways. The compound's distinct electronic properties enable it to modulate reaction kinetics, making it a valuable tool for studying energy transfer and excited-state dynamics in complex systems.

Tide Quencher™ 3WS acid [TQ3WS acid]

sc-460814
5 mg
$245.00
(0)

Tide Quencher™ 3WS acid (TQ3WS acid) exhibits remarkable quenching capabilities through its unique acid halide structure, which facilitates strong hydrogen bonding interactions with surrounding molecules. This enhances the stabilization of excited states, leading to efficient energy transfer processes. Its distinctive reactivity profile allows for rapid deactivation of excited species, making it an effective agent for controlling photochemical reactions and influencing reaction pathways in diverse environments.

Tide Quencher™ 3WS succinimidyl ester [TQ3WS SE]

sc-460815
1 mg
$245.00
(0)

Tide Quencher™ 3WS succinimidyl ester (TQ3WS SE) serves as a potent quencher, characterized by its ability to form stable adducts through nucleophilic attack on its electrophilic ester moiety. This interaction promotes rapid energy dissipation, effectively reducing fluorescence intensity. Its unique structure allows for selective targeting of specific excited states, enhancing the modulation of photophysical properties and enabling precise control over reaction kinetics in various systems.

Tide Quencher™ 3 azide [TQ3 azide]

sc-460816
5 mg
$245.00
(0)

Tide Quencher™ 3 azide (TQ3 azide) is a specialized quencher that exhibits remarkable efficiency in energy transfer processes. Its azide functional group facilitates unique interactions with reactive species, promoting rapid deactivation of excited states. This compound demonstrates distinct reaction kinetics, allowing for fine-tuned modulation of fluorescence signals. Additionally, its stability under various conditions enhances its utility in diverse experimental setups, making it a versatile tool for studying molecular dynamics.