PTP 1β Activators
PTP 1β Activators are diverse chemical compounds that indirectly promote the functional activity of PTP 1β by affecting the phosphorylation state of proteins within its regulatory signaling pathways. Sodium orthovanadate and phenylarsine oxide function by inhibiting the phosphatase activity of PPTP 1β Activators are diverse chemical compounds that indirectly promote the functional activity of PTP 1β by affecting the phosphorylation state of proteins within its regulatory signaling pathways. Sodium orthovanadate and phenylarsine oxide function by inhibiting the phosphatase activity of PTP 1β, maintaining the phosphorylation of tyrosine residues integral to PTP 1β's signaling milieu. Zinc chloride and hydrogen peroxide enhance signaling pathways through a similar mechanism of action, by binding and oxidizing the active site of PTP 1β, respectively, leading to a reduced ability of PTP 1β to dephosphorylate its substrates. Peracetic acid and p-Bromophenacyl bromide also contribute to this enhancement by irreversibly modifying the PTP 1β active site, ensuring prolonged tyrosine phosphorylation. Iodotubercidin increases adenosine levels, which then indirectly activates protein tyrosine phosphorylation cascades under PTP 1β's governance, while Nsc-87877 selectively inhibits PTP 1β, directly increasing tyrosine phosphorylation in the associated pathways.
Oleuropein and cinnamaldehyde add to the list of PTP 1β activators by inhibiting its phosphatase activity, specifically augmenting insulin receptor signaling, which is a known substrate of PTP 1β. Erlotinib, although an EGFR inhibitor, elicits a compensatory cellular response that paradoxically increases PTP 1β pathway activity by enhancing tyrosine phosphorylation. Similarly, Bisphenol A, through its hormonal mimicry, can alter cellular signaling environments and indirectly potentiate the activation of signaling cascades that PTP 1β regulates. Collectively, these compounds achieve enhanced signaling through the pathways regulated by PTP 1β by ensuring a higher state of tyrosine phosphorylation than would occur with the normal activity of PTP 1β, thus promoting the functional outcomes of its associated signaling networks without directly increasing PTP 1β's expression or intrinsic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate acts as a phosphatase inhibitor. By inhibiting phosphatases like PTP 1β, it prevents the dephosphorylation of tyrosine residues on proteins, indirectly maintaining the phosphorylation state that is necessary for the activation of downstream signaling pathways that PTP 1β typically regulates. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
Phenylarsine oxide is an inhibitor of tyrosine phosphatases. By binding to the vicinal cysteines in the active site of PTP 1β, it enhances the phosphorylation of signaling proteins that PTP 1β would normally dephosphorylate, resulting in an increase in signaling activity that PTP 1β is involved with. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can bind to the active sites of tyrosine phosphatases such as PTP 1β, leading to a conformational change and decreased activity. This results in enhanced signaling through pathways that are normally downregulated by PTP 1β activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an oxidizing agent, hydrogen peroxide can oxidize the catalytic cysteine residue in PTP 1β, which inactivates the phosphatase activity and thereby indirectly sustains the tyrosine phosphorylation that activates signaling cascades PTP 1β usually suppresses. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
NSC-87877 selectively inhibits PTP 1β, which leads to an increase in the tyrosine phosphorylation of proteins that are substrates of PTP 1β, thereby enhancing the activity of signaling pathways regulated by PTP 1β. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $359.00 $530.00 $791.00 $6773.00 | 2 | |
Oleuropein has been shown to inhibit PTP 1β activity, which results in the enhancement of insulin receptor signaling by maintaining the phosphorylation state of the receptor, a substrate of PTP 1β. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
While primarily an EGFR inhibitor, erlotinib can lead to compensatory cellular responses that enhance PTP 1β-related signaling pathways. By blocking EGFR, it indirectly causes an increase in tyrosine phosphorylation mediated by pathways where PTP 1β is a regulatory element. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde has been reported to inhibit PTP 1β, which could lead to an enhancement of insulin signaling by preventing the dephosphorylation of the insulin receptor, a process normally regulated by PTP 1β. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is known to interfere with various signaling pathways by its estrogenic activity. It can indirectly result in the activation of signaling cascades involving tyrosine phosphorylation where PTP 1β serves a regulatory role, by altering the hormonal environment that influences these pathways. | ||||||