PSM Inhibitors

The chemical class of PSM inhibitors encompasses a diverse array of compounds targeting various cellular processes and signaling pathways. These inhibitors exert their effects through distinct mechanisms, providing valuable tools for elucidating the regulatory networks governing PSM expression and function. Bafilomycin A1, for instance, disrupts lysosomal acidification by inhibiting vacuolar-type H+-ATPase (V-ATPase), impacting PSM modulation through lysosome-related pathways. Salubrinal selectively inhibits eukaryotic initiation factor 2 alpha (eIF2α) dephosphorylation, inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), contributing to the modulation of PSM levels. Spautin-1, as a deubiquitinase inhibitor, enhances the degradation of specific substrates through the ubiquitin-proteasome system, influencing the turnover of PSM or related proteins. Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, affects multiple cellular processes, influencing the signaling cascades that modulate PSM expression or activity. Dynasore, a dynamin inhibitor, disrupts endocytic processes, impacting the internalization and trafficking of membrane-associated proteins like PSM.Rapamycin, an mTOR inhibitor, modulates various cellular processes, including autophagy and protein synthesis, influencing the expression or turnover of PSM. 2-Deoxyglucose, a glycolysis inhibitor, induces metabolic stress and activates AMP-activated protein kinase (AMPK), impacting cellular signaling pathways related to PSM expression or function. ML-7, an inhibitor of myosin light chain kinase (MLCK), influences cellular processes related to actin organization, affecting the subcellular localization or function of PSM through cytoskeletal modulation. MG-132, a proteasome inhibitor, blocks proteasomal degradation, leading to the accumulation of ubiquitinated proteins and affecting the turnover of PSM or its interacting partners. NSC 23766, a Rac1 inhibitor, impacts cellular processes related to actin organization, influencing the subcellular localization or function of PSM. In conclusion, the chemical class of PSM inhibitors provides a powerful toolkit for dissecting the intricate regulatory mechanisms governing PSM dynamics within the cellular milieu.