PRPF (pre-mRNA processing factor) Activators
Pre-mRNA processing factor signaling is a crucial mechanism in gene expression regulation, ensuring that newly transcribed precursor messenger RNAs (pre-mRNAs) are appropriately modified and processed before being translated into functional proteins. One key player in this process is PRPF3 (pre-mRNA processing factor 3), which is involved in pre-mRNA splicing, a fundamental step where introns are removed and exons are ligated together to create mature mRNA. PRPF3 is part of the SF3b subcomplex within the spliceosome, a large molecular machinery responsible for splicing. While the primary role of PRPF3 is not activation, certain compounds have been identified that can indirectly affect its activity. These compounds, like pladienolide B and herboxidiene, disrupt splicing by targeting the SF3b complex, influencing PRPF3's function and impacting overall splicing fidelity.
The significance of PRPF3 activators lies in their ability to fine-tune the splicing process, thereby affecting gene expression patterns and protein diversity. However, extensive research is needed to understand the precise effects of PRPF3 activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B is a natural compound that has been shown to inhibit splicing by targeting the SF3b subcomplex of the spliceosome, which includes PRPFWhile its primary mode of action is inhibition, it can indirectly affect the activity of PRPF3 by disrupting the splicing process. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene is another natural compound that targets the SF3b complex, including PRPFSimilar to pladienolide B, herboxidiene also functions as a splicing inhibitor, and its effect on PRPF3 is through its disruption of the splicing machinery. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Isoginkgetin is a natural biflavonoid compound found in some plants. It has been shown to have splicing modulatory effects by promoting exon inclusion in certain genes. While its exact mechanism of action is not fully understood, it might impact the activity of splicing factors like PRPF3 indirectly. | ||||||