protein phosphatase (PPP3R1 PPP3R2) Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
A potent immunosuppressant, Cyclosporin A binds to the immunophilin cyclophilin, and the resulting complex inhibits calcineurin, preventing the dephosphorylation of the transcription factor NFAT, which is crucial for T-cell activation. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Similar to Cyclosporin A, Tacrolimus binds to the immunophilin FKBP12, and this complex then inhibits calcineurin. | ||||||
Ascomycin | 104987-12-4 | sc-207303B sc-207303 sc-207303A | 1 mg 5 mg 25 mg | $37.00 $176.00 $322.00 | ||
An analog of Tacrolimus that also binds to FKBP12 and inhibits calcineurin. | ||||||
Voclosporin-d4 | 515814-01-4 unlabeled | sc-475774 sc-475774A sc-475774B | 1 mg 2.5 mg 5 mg | $640.00 $1440.00 $2657.00 | ||
A novel calcineurin inhibitor found in modifications of Cyclosporin A. | ||||||
Pimecrolimus | 137071-32-0 | sc-208172 | 1 mg | $140.00 | 2 | |
Another derivative of Ascomycin, this compound inhibits calcineurin by binding to FKBP12. | ||||||
NFAT Activation Inhibitor III | 3519-82-2 | sc-203160 | 10 mg | $117.00 | 2 | |
A molecule identified to inhibit the NFAT-calcineurin interaction, impacting calcineurin's ability to dephosphorylate NFAT. | ||||||