PPP2R3A Activators
PPP2R3A Activators comprises compounds that indirectly influence PPP2R3A's function through their effects on phosphorylation and dephosphorylation processes within cells. These compounds, by modulating the activity of PP2A, the phosphatase to which PPP2R3A is a regulatory subunit, affect the balance of phosphorylation levels in the cell. Compounds such as Okadaic Acid, Calyculin A, and Cantharidin inhibit PP2A, leading to increased phosphorylation levels of proteins normally targeted by PP2A. This indirect modulation of PP2A activity enhances the functional role of PPP2R3A in regulating cellular phosphorylation states.
Additionally, other compounds in this class, including Forskolin, Caffeine, and Bisindolylmaleimide I, influence PP2A and, consequently, PPP2R3A through different mechanisms. Forskolin and Caffeine, by increasing cAMP levels, and BIM, through PKC inhibition, alter the regulatory environment in which PP2A and PPP2R3A operate. This results in an indirect enhancement of PPP2R3A's role in cellular signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can modulate PP2A activity, indirectly affecting PPP2R3A by altering the phosphorylation status of proteins in cAMP-dependent pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a phosphodiesterase inhibitor, increases cAMP levels, which can indirectly affect PPP2R3A by modulating PP2A activity in cAMP-dependent signaling pathways. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM is a PKC inhibitor. By inhibiting PKC, it affects PP2A regulation, indirectly enhancing PPP2R3A activity by modifying phosphorylation levels of proteins involved in PKC-mediated pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate is a general inhibitor of phosphatases. Its broad inhibition can enhance PPP2R3A activity by increasing overall phosphorylation levels in the cell. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects several signaling pathways including glycogen synthase kinase-3 (GSK-3) inhibition. By modulating these pathways, it can indirectly influence PPP2R3A's role in PP2A-mediated signaling. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a broad-spectrum kinase inhibitor, affects multiple signaling pathways. Its action can indirectly enhance PPP2R3A activity by altering the phosphorylation status of proteins in kinase-mediated pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth. Its inhibition can indirectly affect PPP2R3A activity by altering PP2A-mediated dephosphorylation processes in growth signaling pathways. | ||||||