Polycystin-1 Antibodies

Santa Cruz Biotechnology offers a broad range of Polycystin-1 monoclonal antibodies for research applications. Polycystin-1 Antibodies are applicable in various techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Polycystin-1 is a vital component of the polycystin complex, playing a significant role in cellular signaling and maintaining renal tubular structure. Its dysfunction is associated with autosomal dominant polycystic kidney disease (ADPKD), highlighting its importance in kidney health and disease. Understanding the function of Polycystin-1 is crucial for developing therapeutic strategies for conditions linked to its dysregulation. Research has shown that Polycystin-1 interacts with multiple signaling pathways, influencing cell proliferation, differentiation, and survival. Mutations in Polycystin-1 can lead to structural abnormalities in kidney tissue, making it an important target for therapeutic intervention. Current research focuses on understanding how Polycystin-1 regulates calcium signaling and mechanosensation in kidney cells. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of Polycystin-1 and its role in kidney disease development and progression.