Podocan Activators represent a class of chemicals specifically characterized by their ability to induce the expression of the protein Podocan. Podocan, a member of the small leucine-rich proteoglycan family, plays a pivotal role in the structure and function of the extracellular matrix and is implicated in various biological processes. Podocan Activators, therefore, are thought to interact with cellular mechanisms at the genetic or epigenetic level to enhance the transcription or translation of the Podocan gene. The mechanisms by which these activators function are diverse, reflecting the complexity of gene regulation. Some may bind to receptors or transcription factors, triggering a cascade of intracellular signaling that culminates in the upregulation of Podocan. Others might act by modifying the epigenetic landscape around the Podocan gene, making it more accessible for transcriptional machinery. These chemicals can range from small organic molecules to larger biochemical compounds, each with distinct properties and modes of action that enable them to influence Podocan expression.
The significance of Podocan Activators lies in their role in modulating the cellular and molecular environment where Podocan functions. By influencing Podocan levels, these activators can potentially affect the structure and dynamics of the extracellular matrix, impacting cell adhesion, migration, and signaling. This impact is crucial in understanding the complex interplay of cellular components in various physiological contexts. Moreover, the study of Podocan Activators contributes to the broader understanding of gene regulation, offering insights into the intricate network of interactions that govern protein expression. It's important to recognize that the categorization of these chemicals as Podocan Activators is based on their primary function of influencing Podocan expression; however, like many biochemical agents, they may have secondary actions or effects on other cellular processes. The exploration and characterization of Podocan Activators are thus not only relevant to the field of molecular biology and biochemistry but also contribute to the expanding knowledge of cellular dynamics and protein functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could potentially upregulate Podocan expression through activation of retinoic acid receptors, leading to increased transcription of target genes including Podocan. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol might specifically upregulate Podocan expression by binding to estrogen receptors and activating estrogen-responsive elements in the Podocan gene promoter. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin could enhance Podocan expression by activating adenylate cyclase, increasing cAMP, and subsequently promoting the transcription of cAMP-responsive genes like Podocan. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, could upregulate Podocan expression by increasing chromatin accessibility for transcription factors at the Podocan gene locus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol might promote Podocan expression through activation of sirtuin pathways, leading to changes in gene expression patterns, including the upregulation of Podocan. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could enhance Podocan expression by inhibiting NF-κB, leading to the upregulation of genes negatively regulated by NF-κB, which might include Podocan. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin might upregulate Podocan expression in insulin-responsive tissues by activating insulin signaling pathways, which can lead to increased transcription of certain genes. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin could potentially upregulate Podocan expression via AMPK activation, influencing cellular metabolism and gene transcription patterns. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol might specifically enhance Podocan expression through its active metabolite, calcitriol, which binds to the vitamin D receptor and activates transcription of vitamin D-responsive genes. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone might upregulate Podocan expression by activating glucocorticoid receptors, leading to changes in gene transcription including potential enhancement of Podocan. | ||||||