PLU-1 Inhibitors
PLU-1 inhibitors belong to a distinct chemical class that targets the PLU-1 protein, a critical player in cellular processes. PLU-1, also known as JARID1B or KDM5B, is a histone lysine demethylase involved in epigenetic regulation. The inhibitors of PLU-1 are designed to modulate its enzymatic activity, thereby influencing the demethylation of histone substrates. Histone demethylation is a pivotal mechanism in the epigenetic control of gene expression, and PLU-1, with its demethylase activity on histone H3 lysine 4 (H3K4), plays a central role in this process.
The chemical structure of PLU-1 inhibitors is meticulously crafted to interact with the catalytic site of the PLU-1 enzyme, inhibiting its ability to remove methyl groups from histone substrates. This interference with the demethylation process has implications for the regulation of gene expression, as histone modifications are intimately linked to the activation or repression of specific genes. PLU-1 inhibitors, by modulating the epigenetic landscape, offer a potential avenue for influencing cellular functions that are governed by gene expression patterns. Understanding the structural nuances of these inhibitors is crucial for elucidating their mode of action and exploring their potential impact on cellular processes influenced by histone methylation status.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
A pan-inhibitor of Jumonji histone demethylases, which may affect PLU-1 activity indirectly by modulating histone methylation states. | ||||||
GSK J1 | 1373422-53-7 | sc-391113 sc-391113A | 10 mg 50 mg | $189.00 $797.00 | ||
A selective inhibitor of JmjC domain-containing histone demethylases, which could alter PLU-1 associated pathways by changing histone demethylation patterns. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
The prodrug of GSK-J1, capable of converting to the active compound in cells and influencing JmjC demethylase activity. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine inhibits LSD1, and though LSD1 is a different histone demethylase, its inhibition can have downstream effects on chromatin structure, potentially affecting PLU-1's role. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
A cell-permeable prodrug that inhibits 2-oxoglutarate-dependent dioxygenases, which may indirectly affect PLU-1 function. | ||||||
RN 1 dihydrochloride | 1781835-13-9 | sc-397054 | 10 mg | $205.00 | ||
A selective inhibitor of KDM4A/B demethylases, which can influence chromatin state and potentially impact PLU-1's biological pathways. | ||||||