The chemical class termed PLP-M Activators encompasses a diverse array of compounds that can influence the regulation and expression of the prolactin-like protein M (PLP-M). These activators do not directly engage with PLP-M, but instead, they interact with various upstream signaling pathways and molecular mechanisms, which eventually lead to the modulation of PLP-M expression or activity. The activation process is mediated by the intricate interplay of endogenous biochemical cascades, where one pathway's modulation can ripple through the network, culminating in the upregulation of PLP-M. This class includes substances that interact with hormone receptors, enzyme inhibitors, growth factors, and neurotransmitter regulators, all of which can converge on the signaling pathways that dictate the expression levels of PLP-M.
The interactions that define PLP-M Activators are rooted in their ability to influence the cellular environment and the complex web of intracellular communications. For instance, some of these activators engage with specific receptor types, instigating a cascade of intracellular events that lead to transcriptional changes in genes, including those related to PLP-M. Others may act by altering the balance of neurotransmitters or hormones that, through secondary messenger systems, result in the upregulation of PLP-M. Additionally, certain activators in this class can modulate the activity of proteins involved in cellular growth and proliferation, indirectly influencing the expression of PLP-M as part of the broader response to growth signals. The precise mechanisms by which these chemicals modulate PLP-M are anchored in their ability to shift the dynamics of cellular signaling networks, thereby changing the expression patterns of a multitude of genes, including those encoding for PLP-M.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol can elevate prolactin levels by enhancing the transcription of prolactin gene family members, including Prl2a1, through estrogen receptor signaling. | ||||||
Bromocriptine | 25614-03-3 | sc-337602A sc-337602B sc-337602 | 10 mg 100 mg 1 g | $57.00 $265.00 $567.00 | 4 | |
Although typically a prolactin inhibitor, Bromocriptine can result in increased expression of prolactin gene family members, including Prl2a1, under certain cellular conditions by transient receptor desensitization. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
As a dopamine antagonist, Chlorpromazine can increase the secretion of prolactin, which could possibly activate Prl2a1 by blocking dopamine D2 receptors that normally inhibit prolactin secretion. | ||||||
Metoclopramide | 364-62-5 | sc-358363 | 100 g | $465.00 | 1 | |
Metoclopramide is a dopamine D2 receptor antagonist that can increase prolactin levels, which could possibly activate Prl2a1 by blocking the inhibitory effect of dopamine on prolactin release. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
May increase expression of prolactin family genes, which could possibly activate Prl2a1 through its actions on reproductive tissues and the mammary gland. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Through its various receptors, serotonin can regulate prolactin secretion, which could possibly activate Prl2a1 and in turn, may influence related gene expression. | ||||||