Bromocriptine CAS: 25614-03-3
MF: C32H40BrN5O5
MW: 654.59
A dopaminergic agonist which inhibits release of prolactin.

Bromocriptine (CAS 25614-03-3)

Bromocriptine | CAS 25614-03-3 is rated 5.0 out of 5 by 1.
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Application: Bromocriptine is a dopaminergic agonist which inhibits release of prolactin
CAS Number: 25614-03-3
Purity: ≥97%
Molecular Weight: 654.59
Molecular Formula: C32H40BrN5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Physical State :
Solid
Solubility :
Soluble in water (partly miscible), and methylene chloride.
Storage :
Store at -20° C
Melting Point :
215-218° C (dec.)
Boiling Point :
865.1° C at 760 mmHg (Predicted)
Density :
1.52 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
Optical Activity :
α20/D -195°, c = 1 in methylene chloride)
IC50 :
Dopamine D3 receptor: IC50 = 0.60 nM (human); Dopamine D2 receptor: IC50 = 1.58 nM (human); Alpha-1b adrenergic receptor: IC50 = 3.55 nM (rat); Serotonin 1a receptor: IC50 = 5.64 nM (rat); Serotonin 2b receptor: IC50 = 8.32 nM (human); Alpha-2a adrenergic receptor: IC50 = 15 nM (human)
Ki Data :
Dopamine D3 receptor: Ki= 0.20 nM (human); Dopamine D2 receptor: Ki= 0.53 nM (human); Alpha-1b adrenergic receptor: Ki= 1.96 nM (rat); Alpha-1d adrenergic receptor: Ki= 2.82 nM (rat); Serotonin 1a receptor: Ki= 3.22 nM (rat)
pK Values :
pKa: 9.60 (Predicted), pKb: 6.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
31101
MDL Number :
MFCD00870213
EC Number :
247-128-5
Beilstein Registry :
741357
SMILES :
CC(C)C[[email protected]]1C(=O)N2CCC[[email protected]]2[[email protected]]3(N1C(=O)[[email protected]](O3)(C(C)C)NC(=O)[[email protected]]4CN([[email protected]@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O

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Certificate of Analysis

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Bromocriptine (CAS 25614-03-3)  Product Citations

See how others have used Bromocriptine (CAS 25614-03-3). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 33155660  Int J Mol Med.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Wang et al Wang et al. (Pubmed ID 26297122) found that bromocriptine reduced serum PRL levels and restored the under-expression of DRD2, DAT and TH resulting from metoclopramide dopamine blocking in the rat pituitary gland and hypothalamus. -SCBT Publication Review
Date published: 2015-07-18
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