Date published: 2026-2-22

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PLEKHQ1 Activators

PLEKHQ1 activators encompass a class of chemical compounds that interact with the PLEKHQ1 protein, a molecule encoded by the PLEKHQ1 gene in humans. This protein, while not fully characterized, is postulated to be involved in intracellular signaling processes, possibly interacting with other proteins or cellular components to execute its biological functions. PLEKHQ1 activators, therefore, are molecules designed to enhance or facilitate the activity of PLEKHQ1 within its native cellular environment. These activators may operate through various mechanisms, such as allosteric modulation, where the activator molecule binds to a site distinct from the PLEKHQ1 active or binding site, inducing a conformational change that results in enhanced activity or interaction capability of the protein.

The chemical structures of PLEKHQ1 activators are diverse, reflecting the complex nature of protein-ligand interactions. These compounds may mimic natural ligands of PLEKHQ1 or may represent novel structural motifs that interact with the protein in unique ways. The binding of these activators to PLEKHQ1 can facilitate its interaction with other proteins, enhance its enzymatic activity if any, or stabilize the protein in a conformation that is more active or more readily interacts with other cellular components. By modulating the activity of PLEKHQ1, these activators influence the downstream signaling pathways in which PLEKHQ1 is involved, potentially affecting a range of cellular processes. The development and study of PLEKHQ1 activators contribute significantly to the understanding of PLEKHQ1's role in cell biology and the potential mechanisms by which its activity can be modulated within the cell.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid, a metabolite of Vitamin A, plays a role in cellular differentiation and gene expression. It could potentially influence PLEKHQ1 expression.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

This glucocorticoid can regulate gene expression and might have an indirect effect on PLEKHQ1 levels.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can influence gene expression, potentially including PLEKHQ1

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC) and can modulate gene expression. It might impact PLEKHQ1 levels in certain contexts.

Lipopolysaccharide, E. coli O55:B5

93572-42-0sc-221855
sc-221855A
sc-221855B
sc-221855C
10 mg
25 mg
100 mg
500 mg
$98.00
$171.00
$425.00
$1560.00
12
(2)

LPS, a component of gram-negative bacteria, can stimulate immune cells and influence gene expression, potentially affecting PLEKHQ1.