PLEKHA6 Inhibitors
Chemical inhibitors of Pleckstrin homology domain-containing family A member 6 (PLEKHA6) operate through various mechanisms to impede its signaling function. LY 294002 and Wortmannin are two such inhibitors that target the phosphoinositide 3-kinases (PI3K) pathway, which is upstream of the Akt signaling pathway where PLEKHA6 operates. By inhibiting PI3K, both chemicals prevent the production of phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), a lipid second messenger that is essential for PLEKHA6 to associate with the cell membrane and exert its function. This inhibitory action compromises the localization and function of PLEKHA6. Similarly, ZSTK474 suppresses PI3K activity, resulting in reduced phosphorylation of Akt, which in turn diminishes PLEKHA6 activity. Miltefosine also disrupts the PI3K/Akt pathway, thereby impeding the interaction of PLEKHA6 with phospholipid targets, which is necessary for its signaling pathway.
Akt inhibitors such as Akt Inhibitor VIII, GSK 690693, Perifosine, Triciribine, MK-2206, SH-5, and ARQ 092 directly target Akt, a crucial kinase that PLEKHA6 interacts with. These inhibitors prevent the phosphorylation and subsequent activation of Akt, which is necessary for PLEKHA6-mediated signaling events. Without active Akt, PLEKHA6 cannot propagate its downstream signals, effectively silencing its role within the cell. The SU 9516, while not directly inhibiting PLEKHA6, diminishes the activity of inositol polyphosphate multikinase (IPMK), which is vital for the PI3K/Akt pathway. This reduction in IPMK activity leads to an indirect inhibition of PLEKHA6 by curtailing the phosphoinositide-mediated signaling that PLEKHA6 relies on for its function. Collectively, these chemical inhibitors disrupt the functional activity of PLEKHA6 by targeting different components within its signaling pathway, from the upstream PI3K to the downstream Akt kinase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 inhibits PI3K, which is upstream of Akt signaling; since Pleckstrin homology domain-containing family A member 6 (PLEKHA6) interacts with members of the PI3K-Akt pathway, inhibition of PI3K prevents PLEKHA6 from associating with PtdIns(3,4,5)P3 and inhibits its downstream signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. By inhibiting PI3K, it prevents the production of PtdIns(3,4,5)P3, thus inhibiting the localization and function of PLEKHA6 that requires binding to phosphoinositides. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
Akt Inhibitor VIII directly inhibits Akt, which is a downstream effector of PLEKHA6 in the PI3K-Akt pathway. Inhibition of Akt leads to functional inhibition of PLEKHA6-mediated signaling events. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK 690693 is an Akt inhibitor. By inhibiting Akt kinase activity, it disrupts the phosphorylation on downstream targets of PLEKHA6, functionally inhibiting the signaling pathways in which PLEKHA6 is involved. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine inhibits Akt and downstream signaling. By inhibiting the activation of Akt, Perifosine functionally inhibits PLEKHA6's role in Akt-mediated signaling pathways. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine selectively inhibits the phosphorylation and activation of Akt, which is necessary for PLEKHA6 signaling function. Inhibition of Akt thus leads to inhibition of PLEKHA6 function. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is an allosteric inhibitor of Akt. It impedes Akt signaling, which is crucial for PLEKHA6 function, thereby inhibiting the biological actions of PLEKHA6 in the cell. | ||||||
SU 9516 | 377090-84-1 | sc-222330 sc-222330A | 5 mg 25 mg | $124.00 $391.00 | 3 | |
SU 9516 diminishes the activity of IPMK, which is vital for PI3K/Akt signaling. This indirectly inhibits PLEKHA6 by reducing the phosphoinositide-mediated signaling that PLEKHA6 relies on. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $81.00 | 8 | |
Miltefosine inhibits the PI3K/Akt pathway. By doing so, it prevents PLEKHA6 from interacting with its phospholipid targets and inhibits the associated signaling pathways. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
ZSTK474 inhibits PI3K, leading to a reduction in Akt phosphorylation and activity. This process functionally inhibits the activity of PLEKHA6 by disrupting its associated signaling pathway. | ||||||