PLC γ1 Inhibitors
Common PLC γ1 Inhibitors include, but are not limited to ET-18-OCH3 CAS 77286-66-9, 2-APB CAS 524-95-8, DAG Kinase Inhibitor II CAS 120166-69-0, YM 26734 CAS 144337-18-8 and U-73343 CAS 142878-12-4.
PLC γ1 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Phospholipase C gamma 1 (PLC γ1). PLC γ1 is an enzyme that plays a crucial role in cellular signaling pathways. It is activated in response to various extracellular signals, such as growth factors and G-protein-coupled receptor activation. Upon activation, PLC γ1 catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 acts as a second messenger, mobilizing calcium from intracellular stores, while DAG activates protein kinase C (PKC), initiating downstream signaling cascades that regulate cell growth, differentiation, and other cellular processes.
PLC γ1 inhibitors work by specifically targeting the PLC γ1 enzyme, preventing its activation and the subsequent hydrolysis of PIP2. This inhibition may disrupt the downstream signaling pathways that depend on IP3 and DAG, altering cellular responses to extracellular stimuli. Research into PLC γ1 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in various cellular processes. The study of PLC γ1 inhibitors represents a captivating area of research, contributing to a deeper understanding of the intricate signaling networks and their role in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ET-18-OCH3 | 77286-66-9 | sc-201021 sc-201021A sc-201021B sc-201021C sc-201021F | 5 mg 25 mg 50 mg 100 mg 1 g | $111.00 $436.00 $843.00 $1576.00 $3756.00 | 6 | |
Inhibits PLCγ1 by affecting lipid composition, altering PIP2 levels, and disrupting downstream signaling pathways involved in cell proliferation and survival. Used in research to study the role of PLCγ1 in cellular functions. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Inhibits PLCγ1 activity by modulating the IP3 receptor and interfering with calcium release from the endoplasmic reticulum. Used in research for studying the role of PLCγ1 in calcium signaling and cellular responses. | ||||||
DAG Kinase Inhibitor II | 120166-69-0 | sc-3551 sc-3551A | 5 mg 25 mg | $138.00 $388.00 | 1 | |
Selective inhibitor of PLCγ1, preventing the hydrolysis of PIP2 and inhibiting downstream signaling pathways involved in cell proliferation and survival. Used in research to study the specific functions of PLCγ1. | ||||||
YM 26734 | 144337-18-8 | sc-204410 | 10 mg | $224.00 | 4 | |
Selective inhibitor of PLCγ1, blocking its catalytic domain and reducing PIP2 hydrolysis, leading to inhibition of calcium signaling and downstream cellular responses. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
Inhibits PLCγ1 by preventing its activation through protein kinase C (PKC), reducing calcium release and downstream cellular responses. Investigated in research for potential therapeutic use. | ||||||
U-73343 | 142878-12-4 | sc-201422 sc-201422A | 5 mg 25 mg | $93.00 $350.00 | 17 | |
Inhibits PLCγ1 by blocking its catalytic domain and reducing PIP2 hydrolysis, leading to decreased intracellular calcium release and downstream signaling. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Indirectly activates PLCγ1 by promoting its tyrosine phosphorylation and calcium release. Used in research to study the regulation of PLCγ1 signaling. | ||||||
Cucurbitacin I | 2222-07-3 | sc-203010 | 1 mg | $250.00 | 9 | |
Inhibits PLCγ1 by targeting its catalytic domain and interfering with PIP2 hydrolysis, leading to the reduction of intracellular calcium release and downstream signaling. Investigated in research for its potential therapeutic use. | ||||||