PIG11 Inhibitors
Chemical inhibitors of PIG11 function by disrupting key signaling pathways that are essential for its activity. Wortmannin and LY294002 are both inhibitors of phosphoinositide 3-kinases (PI3K), which play a pivotal role in the PI3K/AKT signaling pathway, a route crucial for the function of many proteins, including PIG11. These inhibitors prevent the phosphorylation and subsequent activation of AKT, a kinase that is known to be upstream of numerous cellular processes. As a result, the activity of PIG11 is suppressed due to the lack of necessary activation signals. Similarly, Triciribine and Perifosine specifically target AKT. Triciribine inhibits the phosphorylation of AKT, while Perifosine impedes its activation. Consequently, these actions result in the functional inhibition of PIG11, as the signaling cascade that PIG11 relies on is interrupted.
Furthermore, Rapamycin and Torin 1 are mTOR inhibitors that lead to the downregulation of processes potentially vital for PIG11's function. By binding to FKBP12 and inhibiting mTOR, Rapamycin disrupts the mTOR signaling pathway, which has downstream effects on protein synthesis and other cellular functions. Torin 1, similarly, is potent in its inhibition of mTOR and thus interferes with the cellular environment required for PIG11 activity. MK-2206, GSK690693, and AZD5363 are additional inhibitors that target AKT. MK-2206 functions as an allosteric inhibitor, GSK690693 competes with ATP to inhibit AKT, and AZD5363 prevents AKT phosphorylation, each leading to a decrease in the downstream signaling necessary for PIG11 activity. Palomid 529, a derivative of Rapamycin, and Miltefosine both act to suppress the mTOR/AKT pathway, contributing to the inhibition of PIG11. Lastly, Spautin-1 promotes the degradation of class I PI3Ks, further reducing PI3K/AKT signaling and, thus, PIG11 activity. Each of these chemicals, by various means, effectively disrupts the signaling pathways that enable PIG11 to function within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways, including those regulating cell growth and survival. Inhibition of PI3K can lead to reduced activity of downstream targets such as AKT, which may be crucial for PIG11 function. With the PI3K/AKT pathway inhibited, PIG11's activity, which relies on the proper signaling through this pathway, is likely to be suppressed. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that prevents the activation of the AKT pathway. Given that PIG11 may operate downstream of PI3K/AKT signaling, LY294002's inhibition of this pathway can suppress PIG11's activity by blocking its necessary activation signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and together they inhibit mTOR (mammalian target of rapamycin), which is a central regulator of cell growth and proliferation. As mTOR is involved in protein synthesis and other cellular processes that could be essential for PIG11 function, Rapamycin's inhibition of mTOR can indirectly lead to the functional inhibition of PIG11. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine specifically inhibits the phosphorylation and activation of AKT. By doing so, it disrupts the signaling pathways that may be necessary for PIG11 activity, leading to its functional inhibition. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an alkylphospholipid that inhibits AKT activation. By inhibiting the AKT signaling pathway, Perifosine can suppress the activity of PIG11 if PIG11 relies on AKT signaling for its function. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is an allosteric inhibitor of AKT which disrupts its signaling capability. This would lead to the downregulation of PIG11's activity if PIG11's functional role is contingent on AKT-mediated signaling. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is a potent inhibitor of mTOR, which like Rapamycin, leads to the inhibition of cellular processes that could be vital for PIG11 functionality, thus resulting in the functional inhibition of PIG11. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693 is an ATP-competitive inhibitor of AKT. By preventing AKT activation, it inhibits downstream signaling required for PIG11 activity, thereby functionally inhibiting PIG11. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AZD5363 is an inhibitor of AKT that prevents its phosphorylation and activation. This action can suppress the pathways PIG11 is involved in, resulting in its functional inhibition. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
Palomid 529 is a derivative of Rapamycin and acts as an inhibitor of mTOR/AKT pathway. It thereby inhibits the function of PIG11 by downregulating the cellular processes that PIG11 might depend upon. | ||||||