pHyde Activators
STEAP3, also known as Six-Transmembrane Epithelial Antigen of the Prostate 3, is a transmembrane protein that belongs to the family of metalloreductases. This chemical class represents compounds or molecules that have the ability to activate or modulate the activity of STEAP3 metalloreductase. STEAP3 itself plays a crucial role in cellular iron metabolism, and its activation or modulation can have significant implications for iron homeostasis within the cell.
STEAP3 metalloreductases are primarily involved in the reduction of ferric iron (Fe³⁺) to ferrous iron (Fe²⁺) within the endosome and lysosome compartments of the cell. This reduction is essential for the efficient uptake of iron from transferrin and its subsequent utilization in various cellular processes. Activators of STEAP3, often referred to as "pHyde Activators," facilitate this reduction process by enhancing the enzymatic activity of STEAP3. These activators may function through various mechanisms, such as altering the protein's conformation, stabilizing its active state, or facilitating electron transfer reactions. By promoting the efficient reduction of ferric iron, these activators can indirectly influence iron-dependent processes, including heme synthesis, DNA replication, and oxygen transport.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Iron(III) chloride | 7705-08-0 | sc-215192 sc-215192A sc-215192B | 10 g 100 g 500 g | $41.00 $46.00 $87.00 | ||
Ferric chloride can provide a source of ferric iron (Fe3+), which can be reduced to ferrous iron (Fe2+) by pHyde. Increasing the availability of Fe3+ may indirectly promote pHyde activity by providing more substrate for reduction. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $73.00 $109.00 | ||
Ferrous sulfate supplies ferrous iron (Fe2+), which can be a substrate for pHyde-mediated reduction. Increasing Fe2+ availability may support pHyde activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid can enhance iron reduction by reducing ferric iron (Fe3+) to ferrous iron (Fe2+), which can then be further processed by pHyde. It indirectly supports pHyde's function by facilitating iron reduction. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NADH is involved in cellular redox reactions. Its presence may indirectly increase pHyde activity by influencing the overall cellular redox state, which can impact iron metabolism. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione participates in cellular redox reactions and may indirectly increase pHyde activity by affecting the redox state of iron ions. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
Trolox is an antioxidant that can affect the cellular redox state, indirectly increasing pHyde activity by altering the availability of reduced iron. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $30.00 $98.00 | 1 | |
BHA is an antioxidant that can affect the cellular redox state, indirectly increasing pHyde activity by altering the availability of reduced iron. | ||||||
Diethylenetriaminepentaacetic acid | 67-43-6 | sc-214890 sc-214890A | 5 g 50 g | $75.00 $234.00 | 1 | |
DTPA is a chelating agent that can sequester metal ions, including iron. Its use may indirectly increase pHyde activity by altering iron availability for reduction. | ||||||