PHF13 Inhibitors

PHF13 inhibitors constitute a diverse group of chemical compounds that modulate the protein's function indirectly by altering the chromatin landscape. These compounds primarily target enzymes involved in the addition or removal of post-translPHF13 inhibitors constitute a diverse group of chemical compounds that modulate the protein's function indirectly by altering the chromatin landscape. These compounds primarily target enzymes involved in the addition or removal of post-translational modifications (PTMs) on histones, such as acetylation and methylation. For instance, Trichostatin A and MS-275 inhibit histone deacetylases, leading to a more relaxed chromatin state that can impair the role of PHF13 in transcriptional regulation. On the other hand, 5-Azacytidine and RG108 inhibit DNA methyltransferases, inducing changes in gene expression that could counteract the function of PHF13.

Similarly, other PHF13 inhibitors affect the function of this protein by targeting histone methyltransferases or proteins that recognize histone modifications. BIX-01294, UNC0638, GSK126, EPZ-5676, and Chaetocin inhibit different histone methyltransferases, leading to alterations in the methylation status of histones that could impact PHF13's chromatin-binding properties. JQ1 and I-BET151, which inhibit bromodomain-containing proteins, and YF2, an inhibitor of the histone demethylase LSD1, can also affect the function of PHF13 by altering the epigenetic landscape.