PHC2 Activators
Polyhomeotic-like protein 2 (PHC2) is a part of the Polycomb group (PcG) proteins, which are essential for the regulation of developmental genes through chromatin remodeling and transcriptional repression. PHC2 is a component of the Polycomb repressive complex 1 (PRC1), which is known for its role in maintaining the transcriptional silencing of genes over successive cell generations, a process known as cellular memory.The PRC1 complex, including PHC2, contributes to the post-translational modification of histones, particularly the monoubiquitination of histone H2A. This modification is a hallmark of PcG-mediated gene repression and is crucial for the stable inheritance of repressed states of gene expression during cell division.
PHC2 is involved in various developmental processes, and its dysregulation can lead to developmental abnormalities and has been associated with cancer. The protein interacts with other PRC1 components to orchestrate the repression of target genes, influencing cell fate decisions, differentiation, and proliferation.Research on PHC2 has provided insights into the molecular mechanisms of epigenetic regulation. It has also underscored the importance of precise control of gene expression during development and the maintenance of stem cell pluripotency.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
May demethylate DNA and induce gene expression, potentially including PHC2. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Known to influence epigenetic modifications and could affect the expression of genes like PHC2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor which could upregulate genes silenced by chromatin remodeling, including PHC2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, it may increase histone acetylation and potentially enhance PHC2 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Can regulate gene expression via retinoid receptors, potentially influencing PHC2 expression as part of differentiation signals. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
The active component of green tea, known for its epigenetic modulatory effects, could hypothetically upregulate PHC2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A phytoestrogen with epigenetic modulating activity, which might affect PHC2 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
May affect gene expression through epigenetic mechanisms, potentially influencing PHC2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known for its epigenetic influence and could possibly induce PHC2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Has potential epigenetic modulating activities that could induce the expression of PHC2. | ||||||