PGBD3 Activators
PGBD3 activators refer to a niche category of chemical agents that specifically interact with PiggyBac Transposable Element Derived 3 (PGBD3), a member of the PiggyBac family of DNA transposases. PGBD3 is a protein that can facilitate the movement of certain DNA elements within the genome, a process which can have significant effects on gene expression and genomic stability. The activators of PGBD3 are designed to enhance the protein's natural transposase activity, potentially influencing the genomic rearrangements it mediates. The modulation of PGBD3 activity by these activators might result in the alteration of its binding affinity to DNA, the facilitation of its dimerization which is often a requisite for transposase activity, or the stabilization of the transposase-DNA complex. These small molecules are crafted to interact with the protein in a way that promotes its engagement with target DNA sequences, thereby possibly impacting the genomic landscape by increasing the rate of transposable element mobilization.
The development of PGBD3 activators is a sophisticated process that hinges on a detailed understanding of the protein's structure and its interaction with DNA. This information guides the design of chemical compounds that can modulate PGBD3 activity with specificity. Once identified, these activators are synthesized and their interactions with PGBD3 are rigorously tested in a variety of assays to ascertain their efficacy in promoting transposase activity. Characteristics such as the compounds' bioavailability, stability, and specificity are also critical parameters that are optimized through iterative chemical synthesis and testing. The creation of PGBD3 activators requires a balance between enhancing the protein's natural activity while maintaining the integrity of its interaction with DNA and the overall cellular environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
that causes DNA cross-linking, leading to DNA damage and potentially inducing the expression of PGBD3 as part of the DNA damage response. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, causing replication stress and potentially triggering a DNA damage response that may upregulate PGBD3. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits topoisomerase I, causing DNA damage and potentially enhancing the expression of PGBD3 within the DNA damage response pathway. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Alkylating agent causing DNA damage, which could potentially activate PGBD3 as the cell responds to DNA lesions. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
An herbicide that may induce genomic stress and could lead to upregulation of DNA repair proteins, including PGBD3. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces oxidative stress and may lead to the activation of stress response pathways that include the expression of PGBD3. | ||||||
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $612.00 | 4 | |
A polycyclic aromatic hydrocarbon that causes DNA adducts and might increase PGBD3 expression in response to genomic instability. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
A heavy metal that induces cellular stress and could potentially enhance the expression of PGBD3 in the cell's attempt to manage the damage. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Causes DNA cross-linking and could potentially lead to the activation of PGBD3 as the cell responds to these specific types of DNA damage. | ||||||