PGAM2 Inhibitors
PGAM2 inhibitors belong to a specific class of chemical compounds that are designed to target and modulate the activity of the enzyme phosphoglycerate mutase 2 (PGAM2). This enzyme plays a crucial role in the glycolytic pathway, which is a central metabolic pathway responsible for the conversion of glucose into energy in the form of adenosine triphosphate (ATP). PGAM2 is specifically involved in the interconversion of 3-phosphoglycerate (3-PG) and 2-phosphoglycerate (2-PG) during glycolysis. Inhibitors of PGAM2 are designed to bind to the active site of the enzyme, thereby interfering with its catalytic activity.
By doing so, these inhibitors regulate the flux of metabolites through the glycolytic pathway, which may have implications for cellular energy production and various other downstream metabolic processes. The development and study of PGAM2 inhibitors provide insights into the intricate regulation of glycolysis and its interconnected pathways. Researchers aim to elucidate the structural and mechanistic aspects of these inhibitors to gain a deeper understanding of their mode of action and impact on cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Non-specific inhibition of PGAM2 enzyme activity through reversible binding. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Non-selective NSAID that inhibits PGAM2 by disrupting substrate binding. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Reversible inhibition of PGAM2 enzyme through interference with substrate. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $41.00 | ||
Competitive inhibition of PGAM2, reducing the conversion of PGA to PGE2. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Irreversible inhibition of PGAM2 by acetylating the enzyme's active site. | ||||||
Diclofenac acid | 15307-86-5 | sc-357332 sc-357332A | 5 g 25 g | $109.00 $298.00 | 5 | |
Inhibition of PGAM2 activity via reversible binding and competitive blocking. | ||||||
Meloxicam | 71125-38-7 | sc-200626 sc-200626A sc-200626B | 20 mg 100 mg 500 mg | $36.00 $94.00 $156.00 | 3 | |
COX-2 selective inhibitor that indirectly affects PGAM2 activity. | ||||||
Vioxx | 162011-90-7 | sc-208486 | 100 mg | $190.00 | 3 | |
Selective COX-2 inhibitor leading to reduced PGAM2 activity and PGE2 levels. | ||||||
Etodolac | 41340-25-4 | sc-204747 sc-204747A | 100 mg 250 mg | $89.00 $131.00 | 1 | |
NSAID that inhibits PGAM2 enzyme, reducing PGE2 production. | ||||||
Flurbiprofen | 5104-49-4 | sc-202158 sc-202158A | 100 mg 1 g | $70.00 $106.00 | ||
Non-selective NSAID with inhibitory effects on PGAM2 enzyme activity. | ||||||