Molecular structure of Flurbiprofen, CAS Number: 5104-49-4
Flurbiprofen (CAS 5104-49-4)
Alternate Names:
Ansaid
Application:
Flurbiprofen is a potent inhibitor of Cox-1 and Cox-2
CAS Number:
5104-49-4
Purity:
≥98%
Molecular Weight:
244.3
Molecular Formula:
C15H13FO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Flurbiprofen is a molecule of interest in the field of biochemistry, where it is often utilized as a tool to study the cyclooxygenase (COX) enzymes responsible for the biosynthesis of prostanoids, including prostaglandins, thromboxanes, and prostacyclins. Research involving flurbiprofen focuses on elucidating the COX isoform selectivity and understanding the enzyme′s role in various biological signaling pathways. The compound′s inhibitory effects on COX activity are leveraged in biochemical assays to probe the enzyme′s structure-function relationship and to investigate the molecular mechanisms underlying enzyme inhibition. In materials science, flurbiprofen is also used in the development of chemical delivery systems, where its physicochemical properties are relevant to the design of controlled-release formulations.
Flurbiprofen (CAS 5104-49-4) References
- Rational design of potent human transthyretin amyloid disease inhibitors. | Klabunde, T., et al. 2000. Nat Struct Biol. 7: 312-21. PMID: 10742177
- Selectivity of cyclo-oxygenase inhibitors in human pulmonary epithelial and smooth muscle cells. | Range, SP., et al. 2000. Eur Respir J. 15: 751-6. PMID: 10780769
- Constitutive cyclooxygenase-1 and induced cyclooxygenase-2 in isolated human iris inhibited by S(+) flurbiprofen. | van Haeringen, NJ., et al. 2000. J Ocul Pharmacol Ther. 16: 353-61. PMID: 10977131
- Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. | Jantzen, PT., et al. 2002. J Neurosci. 22: 2246-54. PMID: 11896164
- Topical flurbiprofen toxicosis in a cat. | Yi, EM. and Leech, E. 2017. J Vet Emerg Crit Care (San Antonio). 27: 707-712. PMID: 28834579
- Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains. | de Bruin, N., et al. 2018. Chirality. 30: 632-641. PMID: 29406583
- Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2. | Karmali, RA. and Marsh, J. 1986. Prostaglandins Leukot Med. 23: 11-4. PMID: 3090559
- Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue. | Saretz, S., et al. 2021. Molecules. 26: PMID: 34064783
- Comparison of percutaneous permeation profiles of flurbiprofen enantiomers. | Zhang, L., et al. 2022. Chirality. 34: 894-900. PMID: 35411968
- Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2. | Karmali, RA. and Marsh, J. 1985. Prostaglandins Leukot Med. 20: 283-6. PMID: 3937158
- Potencies of leflunomide and HR325 as inhibitors of prostaglandin endoperoxide H synthase-1 and -2: comparison with nonsteroidal anti-inflammatory drugs. | Curnock, AP., et al. 1997. J Pharmacol Exp Ther. 282: 339-47. PMID: 9223572
- R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer. | Wechter, WJ., et al. 1997. Cancer Res. 57: 4316-24. PMID: 9331093
- Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. | Riendeau, D., et al. 1997. Can J Physiol Pharmacol. 75: 1088-95. PMID: 9365818
Inhibitor of:
AKR1C13, AKR1C19, APLP1, Cox-2, Enzyme, HRSP12, Manic Fringe, PGAM2, PGE Synthase, PGT, PION, pS2, Slc22a27, SVCT1, UGT1A8, and Ym1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flurbiprofen, 100 mg | sc-202158 | 100 mg | $69.00 | |||
Flurbiprofen, 1 g | sc-202158A | 1 g | $104.00 |