PFK-2 tes Inhibitors
PFK-2 tes inhibitors are a class of chemical compounds that specifically target and inhibit the enzyme phosphofructokinase-2 (PFK-2), a critical regulator of glucose metabolism through its role in the synthesis of fructose-2,6-bisphosphate. PFK-2 is a bifunctional enzyme that possesses both kinase and phosphatase activities, controlling the levels of fructose-2,6-bisphosphate, which in turn regulates phosphofructokinase-1 (PFK-1), a key enzyme in glycolysis. By inhibiting PFK-2, these compounds alter the balance between glycolysis and gluconeogenesis, affecting how cells utilize glucose for energy production. PFK-2 tes refers to a tissue-specific isoform of PFK-2, which can vary in function depending on the metabolic needs of the tissue, such as liver or muscle, where it is expressed.
The mechanism of PFK-2 tes inhibitors typically involves blocking the kinase activity of the enzyme, preventing it from synthesizing fructose-2,6-bisphosphate and thereby reducing the activation of PFK-1. This inhibition shifts the metabolic balance, influencing glucose metabolism, energy production, and the overall metabolic state of the cell. Researchers use PFK-2 tes inhibitors to study the regulation of glycolysis and gluconeogenesis, exploring how metabolic pathways are finely controlled at the enzymatic level. By inhibiting PFK-2 tes, scientists can gain insights into how cells regulate energy production, glucose uptake, and carbohydrate metabolism in response to changes in energy demand or nutrient availability. These inhibitors are valuable tools for understanding the complex regulation of metabolic pathways, particularly in tissues with high metabolic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
This glucose analog competes with glucose and can inhibit its uptake and phosphorylation, potentially leading to a cellular state that suppresses the need for PFK-2, thereby decreasing its expression. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $60.00 $125.00 | 5 | |
By inhibiting pyruvate dehydrogenase kinase, this compound may shift the cell's reliance away from glycolysis, consequently leading to a decrease in PFK-2 expression as the cell adapts its metabolism. | ||||||
Oxamic acid | 471-47-6 | sc-250620 | 25 g | $145.00 | ||
This lactate dehydrogenase inhibitor can disrupt the glycolysis pathway, potentially resulting in reduced PFK-2 synthesis as the cell attempts to balance its disrupted energy metabolism. | ||||||
Lonidamine | 50264-69-2 | sc-203115 sc-203115A | 5 mg 25 mg | $103.00 $357.00 | 7 | |
This compound inhibits hexokinase, a key glycolytic enzyme, which may lead to a decreased demand for PFK-2 activity and result in lowered expression levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As an inhibitor of certain tyrosine kinases, genistein can downregulate several cellular pathways, which might lead to the suppression of PFK-2 expression in certain cancer cell types. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
This plant flavonoid has been shown to downregulate glycolytic enzymes in cancer cells, which suggests that it might also reduce the expression of PFK-2 by disrupting the glycolytic flux. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Known for its ability to enhance sirtuin activity, resveratrol can induce changes in the expression of genes involved in energy homeostasis, including the potential downregulation of PFK-2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
As a histone deacetylase inhibitor, sodium butyrate can lead to changes in chromatin structure, which could result in a decrease in PFK-2 transcription and consequent enzyme expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can induce DNA demethylation, which might lead to the downregulation of genes associated with cancer cell metabolism, including a potential decrease in PFK-2 expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Known to downregulate the expression of multiple transcription factors, triptolide could lead to a comprehensive suppression of metabolic genes, potentially including PFK-2. | ||||||