PEPD Inhibitors
PEPD inhibitors represent a class of compounds that interact with the prolidase enzyme, also known as peptidase D (PEPD), which plays a key role in the breakdown of proline-containing dipeptides and the turnover of collagen. These inhibitors are not selective for PEPD but rather affect the enzyme's activity through indirect mechanisms. Most of the compounds listed are known to inhibit metalloproteases, a category of enzymes that use a metal ion, usually zinc or manganese, in their catalytic mechanism. PEPD is a manganese-dependent enzyme, and thus, inhibitors that chelate metal ions can have an inhibitory effect on its activity.
PEPD inhibitors bind to metal ions and sequester them, thereby removing the essential cofactors needed for PEPD's enzymatic function. This interference with the metal-dependent catalytic site can lead to a reduction in the enzyme's ability to process its natural substrates. The PEPD inhibitors affect PEPD by sequestering the metal ions, particularly manganese, that are essential for the enzyme's activity. This chelation results in an inactive enzyme incapable of binding to or processing its natural substrates. Similarly, inhibitors can also bind to the metal ions within the PEPD active site. This competitive inhibition can reduce the enzyme's ability to interact with its specific dipeptide substrates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bestatin | 58970-76-6 | sc-202975 | 10 mg | $131.00 | 19 | |
Inhibits aminopeptidases, which may reduce the availability of amino acids necessary for the function of PEPD, also known as prolidase, involved in the final step of breaking down proline-containing dipeptides. | ||||||
Chloroform | 67-66-3 | sc-239527A sc-239527 | 1 L 4 L | $112.00 $204.00 | 1 | |
Serves as an inhibitor of various aminopeptidases, potentially altering the amino acid balance and indirectly impairing PEPD function. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $49.00 $91.00 | 21 | |
While primarily an ACE inhibitor, it also has been found to inhibit metalloproteases by chelating the active site metal ion, which might affect the metal-dependent enzyme PEPD. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
A calcium chelator that, while more selective than EDTA, can still affect calcium-dependent processes and possibly interfere with metal ions involved in PEPD's function. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
A metal chelator that, by binding with metal ions, can inhibit metalloenzymes such as PEPD by removing essential metal cofactors from the enzyme's active site. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
A naturally occurring antibiotic that inhibits a variety of peptidases, potentially altering peptide metabolism and indirectly affecting the function of PEPD. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Known as a tetracycline antibiotic, it also acts as a non-selective inhibitor of metalloproteases due to its ability to chelate metal ions, potentially affecting PEPD activity. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
A broad-spectrum metalloprotease inhibitor that can bind to the active site metal ions, potentially reducing the enzymatic activity of PEPD. | ||||||