PDGF-C Activators
The chemicals identified as PDGF-C activators provide insight into the complex signaling networks that regulate PDGF-C expression and activation. Fasudil and Y-27632, through their indirect action on the RhoA/ROCK pathway, exemplify the role of cytoskeletal dynamics in modulating PDGF-C. By inhibiting ROCK, these compounds disrupt the negative regulation on PDGF-C, allowing for increased activation. Tocopherol (Vitamin E), Quercetin, and Luteolin, acting as antioxidants, indirectly activate PDGF-C by influencing the PI3K/Akt signaling pathway. Their ability to enhance cellular redox status promotes PI3K/Akt signaling, contributing to the upregulation of PDGF-C. This highlights the interplay between cellular antioxidant defenses and the modulation of PDGF-C signaling. 4-Hydroxytamoxifen, through its interaction with estrogen receptors (ER), indirectly activates PDGF-C. By binding to ER, 4-hydroxytamoxifen triggers signaling cascades, including those involving PDGF-C. This reveals a connection between hormonal signaling and PDGF-C activation, showcasing the complexity of the regulatory networks involved.
YC-1, by stabilizing HIF-1α, indirectly activates PDGF-C. The activation of HIF-1α-dependent genes, including PDGF-C, illustrates the link between oxygen sensing and PDGF-C regulation. This highlights the role of cellular oxygen levels in shaping PDGF-C expression. Trolox (Water-soluble vitamin E), Genistein, and A-769662, through their influence on the PI3K/Akt pathway, contribute to the activation of PDGF-C. These compounds, representing vitamin E analogs, isoflavones, and AMPK activators, respectively, showcase the abilities of diverse compounds in modulating PDGF-C through intracellular signaling pathways. Betulinic Acid and Nordihydroguaiaretic Acid (NDGA), by inhibiting the NF-κB pathway, indirectly activate PDGF-C. The suppression of NF-κB signaling by these compounds relieves its inhibitory effects on PDGF-C expression, leading to increased activation. This underscores the intricate interplay between inflammatory signaling and the regulation of PDGF-C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 activates PDGF-C indirectly by inhibiting Rho-associated protein kinase (ROCK). Through ROCK inhibition, Y-27632 modulates the RhoA/ROCK pathway, relieving the negative regulation on PDGF-C expression and leading to enhanced activation. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $25.00 $51.00 $122.00 $320.00 | 3 | |
Tocopherol activates PDGF-C by influencing the PI3K/Akt signaling pathway. Acting as an antioxidant, tocopherol promotes PI3K/Akt pathway activation, which has been linked to increased PDGF-C expression. This indirect activation highlights the crosstalk between cellular redox status and PDGF-C signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates PDGF-C indirectly through the PI3K/Akt pathway. As a flavonoid with antioxidant properties, quercetin enhances PI3K/Akt signaling, contributing to increased PDGF-C expression. This highlights the role of cellular antioxidants in modulating PDGF-C activation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin activates PDGF-C indirectly by influencing the PI3K/Akt signaling pathway. As a flavonoid, luteolin enhances PI3K/Akt signaling, contributing to increased PDGF-C expression. This underlines the potential of dietary compounds in modulating PDGF-C activation through intracellular signaling pathways. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $32.00 $122.00 $214.00 $928.00 | 9 | |
YC-1 activates PDGF-C indirectly by influencing the HIF-1α pathway. Through its role as a HIF-1α stabilizer, YC-1 promotes the expression of genes, including PDGF-C, that are under the control of HIF-1α. This indirect activation underscores the connection between cellular oxygen sensing and PDGF-C regulation. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $37.00 $66.00 $230.00 $665.00 $1678.00 | 39 | |
Trolox activates PDGF-C by modulating the PI3K/Akt signaling pathway. As a water-soluble analog of vitamin E, Trolox enhances PI3K/Akt signaling, contributing to increased PDGF-C expression. This highlights the potential of vitamin E derivatives in influencing PDGF-C activation through cellular signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates PDGF-C indirectly through the PI3K/Akt pathway. As an isoflavone with tyrosine kinase inhibitory properties, genistein enhances PI3K/Akt signaling, contributing to increased PDGF-C expression. This underlines the potential of dietary compounds in modulating PDGF-C activation through intracellular signaling pathways. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662 activates PDGF-C indirectly by enhancing AMP-activated protein kinase (AMPK) activity. Through AMPK activation, A-769662 modulates downstream signaling pathways, including those related to PDGF-C expression. This indirect activation highlights the role of cellular energy sensing in influencing PDGF-C activation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid activates PDGF-C indirectly by inhibiting the NF-κB pathway. By suppressing NF-κB signaling, betulinic acid relieves its inhibitory effects on PDGF-C expression, leading to increased activation. This highlights the interplay between inflammatory signaling and PDGF-C modulation. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
NDGA activates PDGF-C indirectly by inhibiting the NF-κB pathway. By suppressing NF-κB signaling, NDGA relieves its inhibitory effects on PDGF-C expression, leading to increased activation. This underscores the potential of natural compounds in modulating PDGF-C activation through the regulation of inflammatory pathways. | ||||||