Trolox CAS: 53188-07-1
MF: C14H18O4
MW: 250.29
An antioxidant derived from water-soluble vitamin E.

Trolox (CAS 53188-07-1)

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Synonym: 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Application An antioxidant derived from water-soluble vitamin E
CAS 등록번호: 53188-07-1
순도: ≥97%
분자량: 250.29
분자식: C14H18O4
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid (sc-204753) and p-coumaric acid (sc-215648). Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii.


References

1. Pannala, A.S., et al. 1998. Free Radic. Biol. Med. 24: 594-606. PMID: 9559872

2. Brookes, P.S., et al. 1998. J. Neurochem. 70: 2195-2202. PMID: 9572308

3. Chen, Q. and Cederbaum, A.I. 1998. Mol. Pharmacol. 53: 638-648. PMID: 9547353

4. Bian, X. et al. 2001. J. Biol. Chem. 276(52): 48921-48929. PMID: 11679590

5. Cuperus, R. et al. 2008. Int. J. Oncol. 32(5): 1011-1019. PMID: 18425327

6. Jung, M.Y. and Min, D.B. 2009. J. Food Sci. 74: C449-C455. PMID: 19723181

7. Ruebhart, D.R., et al. 2009. J. Toxicol. Environ. Health Part A. 72: 1567-1575. PMID: 20077231

8. Kaur, P., et al. 2010. Toxicology. 276: 73-78. PMID: 20637824

9. Mitchell, R.M. et al. 2011. Neurobiol. Aging. 32(6): 1114-1123. PMID: 19560233

10. Okamoto, A. et al. 2016. BMC Anesthesiol. 16(1): 104. PMID: 27776485

Physical State :
Solid
용해도 :
Soluble in 100% ethanol (25 mg/ml), methanol, water(slightly), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS( pH7.2) (~3 mg/ml).
저장 :
Store at -20° C
녹는점 :
187-189° C
비등점 :
~405.3° C at 760 mmHg (Predicted)
밀도 :
~1.2 g/cm3 (Predicted)
굴절률 :
n20D 1.57
IC50 :
Rattus norvegicus: EC5050 = 77.8 µM; COX2: IC50 = 150 nM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 3.6 µM (human); Bos taurus: IC50 = 5 µM; COX1: IC50 = 130 nM (human); Rattus norvegicus: IC50 = 14 µM; Brain: IC50 = 41.57 µM (Rattus norvegicus); MCF7 (Breast carcinoma cells): IC50 = 1461 µM (human); Radical scavenging activity: IC50 = 10.6 µM
pK Values :
pKa: 3.35
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
2
RTECS :
DJ2273000
PubChem CID :
40634
MDL Number :
MFCD00006846
EC Number :
258-422-8
Beilstein Registry :
1384051
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O

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Trolox  논문정보

다른 사용자의 Trolox사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 10 of {3} total

PMID: # 30769341  2019. Phys Biol. 16: 035002.

PMID: # 28211872  2017. Cell Death Differ. 24: 731-746.

PMID: # 29162859  Kondratskyi, A. et al. 2017. Sci Rep. 7: 15896.

PMID: # 28223427  Noguchi, F. et al. 2017. Mol. Cancer Ther. 16: 936-947.

PMID: # 29038291  Goji, T.|Takahara, K.|Negishi, M.|Katoh, H.| et al. 2017. J. Biol. Chem. 292: 19721-19732.

PMID: # 28887471  Tang, J. et al. 2017. Sci Rep. 7: 10945.

PMID: # 27178823  Yin, P.|Jia, J.|Li, J.|Song, Y.|Zhang, Y.|Chen, F.| et al. 2016. Oncol. Res. 24: 65-72.

PMID: # 27383327  2016. Eur Rev Med Pharmacol Sci. 20: 2710-7.

PMID: # 26200654  Penzo-Méndez, AI. et al. 2015. PloS one. 10: e0132437.

PMID: # 25301069  Skliris, A. et al. 2015. Cell Death Differ. 22: 703-18.

Citations 1 to 10 of {3} total
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