PBGD Inhibitors
PBGD inhibitors are chemicals that modulate the activity of the enzyme porphobilinogen deaminase (PBGD). This enzyme plays a crucial role in the heme biosynthesis pathway, which is responsible for the production of heme, an essential molecule involved in various physiological processes, such as oxygen transport and electron transfer. PBGD inhibitors exert their effects by binding to the active site of the enzyme, thereby disrupting its normal function.
This interference can lead to alterations in the production of porphobilinogen, a precursor molecule in heme synthesis. By targeting PBGD, these inhibitors can potentially influence the balance of porphyrin and heme production within cells. The intricate regulation of heme biosynthesis underscores the significance of PBGD inhibitors as valuable tools for studying cellular processes and could potentially have implications in various scientific and research contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferiprone | 30652-11-0 | sc-211220 sc-211220A | 1 g 5 g | $124.00 $134.00 | 5 | |
Deferiprone is a chelator that removes transferrin and ferritin in vitro | ||||||
Phenylhydrazine | 100-63-0 | sc-250701 sc-250701A | 5 g 100 g | $45.00 $52.00 | ||
Phenylhydrazine is known to inhibit PBGD activity by causing oxidative stress and disrupting the heme biosynthesis pathway. It is often used in experimental settings to induce porphyria-like symptoms. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $41.00 $61.00 $194.00 | 11 | |
Acetaminophen, commonly used as a pain reliever, has been found to inhibit PBGD activity at high concentrations. This inhibition contributes to its association with drug-induced porphyria. | ||||||
6-Azauridine | 54-25-1 | sc-221082B sc-221082 sc-221082C sc-221082A | 500 mg 1 g 2 g 5 g | $97.00 $159.00 $295.00 $679.00 | ||
6-Azauridine is a pyrimidine analog that has been shown to inhibit PBGD activity. It interferes with the enzymatic reaction by binding to the active site of PBGD. | ||||||