PARP-11 Inhibitors

PARP-11 inhibitors belong to a specialized class of chemical compounds designed to selectively target and inhibit the enzyme known as Poly(ADP-ribose) polymerase 11 (PARP-11). These inhibitors are part of a broader group of molecules called PARP inhibitors, which have gained significant attention in recent years due to their potential in various biological processes. PARP-11 is a member of the PARP family of enzymes, which play crucial roles in DNA repair, genomic stability, and the maintenance of cellular integrity.

PARP-11 inhibitors are designed to interfere with the enzymatic activity of PARP-11 by binding to its active site, thereby preventing it from catalyzing the transfer of ADP-ribose units onto target proteins. This inhibition of PARP-11 activity may have implications in processes related to DNA damage response and repair, cellular signaling pathways, and possibly other cellular functions. By selectively targeting PARP-11, researchers aim to gain a better understanding of its specific roles in cellular processes and potentially identify novel strategies for modulating these pathways for various purposes. While PARP-11 inhibitors are part of the broader PARP inhibitor class, their unique selectivity for PARP-11 makes them valuable tools for research in cell biology and molecular biology, shedding light on the intricacies of cellular functions and offering opportunities for the development of innovative approaches in the field.