Date published: 2025-10-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

Paraxis Inhibitors

The chemical class known as Paraxis Inhibitors represents a group of organic compounds that exert their effects by modulating the activity of the Paraxis protein. Paraxis is a transcription factor involved in the regulation of various developmental processes in organisms, playing a pivotal role in embryogenesis, tissue differentiation, and organ formation. Paraxis achieves its regulatory function by binding to specific DNA sequences and controlling the expression of target genes. Paraxis Inhibitors are designed to interact with Paraxis either directly or indirectly, leading to a disruption in its normal transcriptional activity. Structurally, Paraxis Inhibitors can exhibit a diverse range of chemical compositions, with variations in their functional groups, aromatic rings, and stereochemistry. These variations allow for the design of compounds with specific binding affinities and selectivities towards the Paraxis protein.

he inhibitory mechanism typically involves either blocking the DNA binding site of Paraxis, preventing its interaction with regulatory regions, or interfering with its protein-protein interactions with co-factors necessary for its transcriptional activity. This disruption of Paraxis function ultimately results in downstream effects on the expression of target genes that contribute to various developmental processes. The discovery and development of Paraxis Inhibitors represent a significant advancement in our understanding of the molecular mechanisms that underlie development and differentiation. By offering a means to manipulate Paraxis activity, researchers gain a valuable tool for investigating its precise role in different biological contexts. Moreover, Paraxis Inhibitors hold promise for uncovering novel insights into the intricate regulatory networks governing embryonic development and tissue homeostasis. As our knowledge of Paraxis and its interactions deepens, these inhibitors could potentially lead to new avenues for intervention in various cellular processes, though their exact applications are still a subject of ongoing research and exploration.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Olaparib

763113-22-0sc-302017
sc-302017A
sc-302017B
250 mg
500 mg
1 g
$206.00
$299.00
$485.00
10
(1)

Inhibits PARP-1/2 enzymes, trapping them on DNA lesions, leading to DNA repair blockade and synthetic lethality in BRCA-deficient cells.

Rucaparib

283173-50-2sc-507419
5 mg
$150.00
(0)

Selectively binds to PARP-1/2, preventing DNA repair and causing cell death, particularly in tumors with BRCA mutations.

Niraparib

1038915-60-4sc-507492
10 mg
$150.00
(0)

Inhibits PARP-1/2, impeding DNA repair and promoting apoptosis, especially in cancer cells with defective homologous recombination.

Talazoparib

1207456-01-6sc-507440
10 mg
$795.00
(0)

Binds to PARP-1/2 at DNA damage sites, disrupting DNA repair pathways and inducing cell death, with potency against BRCA-mutated cancers.

Veliparib

912444-00-9sc-394457A
sc-394457
sc-394457B
5 mg
10 mg
50 mg
$178.00
$270.00
$712.00
3
(0)

Interferes with PARP-1/2 activity, causing DNA damage accumulation and sensitizing tumor cells, especially in combination therapies.