Paraxis Activators
Paraxis Activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of Paraxis through distinct signaling pathways and biological processes pivotal in muscle differentiation and development. Compounds such as Forskolin and Dibutyryl cAMP elevate cAMP levels, leading to PKA activation; this could augment the transcriptional collaboration of Paraxis with other factors, furthering its role in myogenesis. Similarly, Lithium Chloride and BIO accentuate Paraxis activity by inhibiting GSK-3 and, consequently, invigorating the Wnt signaling pathway, which is known to intersect with Paraxis's functional domain in embryonic development. PMA, through PKC activation, and SB431542, by curtailing TGF-beta signaling, offer additional layers of regulation that might indirectly amplify the influence of Paraxis on muscle cell lineage commitment. These mechanisms, together with CHIR99021's GSK-3 inhibition, create a conducive transcriptional milieu for Paraxis to operate within its developmental repertoire.
Paraxis Activators are a diverse set of chemical compounds that indirectly intensify the functional activity of Paraxis, each through modulation of distinct signaling pathways integral to muscle differentiation and embryonic development. Forskolin and Dibutyryl cAMP, by increasing cAMP levels, could potentiate Paraxis by facilitating the phosphorylation of associated transcription factors, thus enhancing its role in muscle cell differentiation. Retinoic Acid, acting through its receptors, may fine-tune the transcriptional networks involving Paraxis, thereby augmenting its developmental functions. Additionally, Lithium Chloride and BIO, through inhibition of GSK-3 and subsequent activation of the Wnt/β-catenin pathway, could indirectly bolster Paraxis's activity by promoting the formation and stabilization of transcriptional complexes crucial for developmental gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can activate PKA. PKA may enhance Paraxis activity by phosphorylating transcription factors that work cooperatively with Paraxis in muscle cell differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways, potentially enhancing Paraxis by promoting its interaction with other transcription factors involved in somitogenesis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression through retinoic acid receptors. It could enhance Paraxis function by influencing the transcriptional programs that Paraxis is a part of during embryonic development. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, leading to the activation of Wnt signaling. Since Paraxis is downstream of Wnt signaling in certain contexts, this inhibition could enhance Paraxis activity in developmental pathways. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO is a GSK-3 inhibitor that activates the Wnt/β-catenin pathway, potentially enhancing Paraxis by stabilizing transcriptional complexes that Paraxis forms with other proteins in the regulation of developmental genes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C, which can modulate transcriptional networks. This activation may indirectly enhance Paraxis by influencing gene expression patterns relevant to its function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of TGF-beta receptors, which might enhance Paraxis by reducing competitive signaling pathways, thus indirectly promoting pathways where Paraxis is involved in muscle development. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR99021 is a GSK-3 inhibitor, which may enhance Paraxis by promoting the stabilization and activity of transcriptional complexes that include Paraxis in developmental processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor, which could lead to the enhancement of Paraxis activity by altering the balance of signaling pathways that influence the transcriptional programs Paraxis participates in. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, potentially enhancing Paraxis by influencing energy balance and metabolic signaling pathways relevant to muscle differentiation and development. | ||||||